Truman Penelope
Institute of Environmental Science & Research, Kenepuru Science Centre, P.O. Box 50348, Porirua, New Zealand.
Toxicon. 2007 Aug;50(2):251-5. doi: 10.1016/j.toxicon.2007.03.016. Epub 2007 Mar 28.
Crude lipophilic toxin from Karenia brevisulcata has been shown to be toxic to mammalian neuroblastoma (Neuro2A) cells in culture. This toxicity is partially antagonised by the addition of saxitoxin. The dose-response curves of saxitoxin acting to antagonise the action of K. brevisulcata toxin and of brevetoxin were examined and they displayed similar EC50 values. These results suggest that at least some of the effect on Neuro2A cells of the lipophilic toxicity found in K. brevisulcata results from an interaction with the mammalian voltage-dependent sodium channel.
来自短裸甲藻的粗亲脂性毒素已被证明对培养中的哺乳动物神经母细胞瘤（Neuro2A）细胞有毒性。添加石房蛤毒素可部分拮抗这种毒性。研究了石房蛤毒素拮抗短裸甲藻毒素和短裸甲藻毒素作用的剂量反应曲线，它们显示出相似的半数有效浓度（EC50）值。这些结果表明，短裸甲藻中发现的亲脂性毒性对Neuro2A细胞的至少部分影响是由与哺乳动物电压依赖性钠通道的相互作用引起的。
