Szabó Eva, Boehm Günther, Beermann Christopher, Weyermann Maria, Brenner Hermann, Rothenbacher Dietrich, Decsi Tamás
Department of Paediatrics, University of Pécs, Pécs, Hungary.
Am J Clin Nutr. 2007 May;85(5):1320-6. doi: 10.1093/ajcn/85.5.1320.
Several observational studies indicate that trans isomeric fatty acids may interfere with the metabolism of essential fatty acids in the human organism.
The objective was to investigate the relation between trans fatty acids and long-chain polyunsaturates in mature human milk.
Human milk samples (n=769) were obtained at the 6th week of lactation from mothers participating in a birth cohort study in Germany. The fatty acid composition of the milk samples was measured by high-resolution capillary gas-liquid chromatography.
trans Octadecenoic and trans octadecadienoic acids were inversely correlated with linoleic acid (r=-0.32 and -0.33, P<0.0001 for both), alpha-linolenic acid (r=-0.35 and -0.27, P<0.0001), arachidonic acid (r=-0.60 and -0.47, P<0.0001), and docosahexaenoic acid (r=-0.51 and -0.33, P<0.0001). In contrast, no inverse correlations were observed between trans hexadecenoic acid and polyunsaturated fatty acids.
The data obtained in the present study suggest that the availability of 18-carbon trans isomeric fatty acids may be inversely related to the availability of long-chain polyunsaturated fatty acids in mature human milk.
多项观察性研究表明，反式异构脂肪酸可能会干扰人体组织中必需脂肪酸的代谢。
本研究旨在调查成熟母乳中反式脂肪酸与长链多不饱和脂肪酸之间的关系。
从参与德国一项出生队列研究的母亲中，在哺乳期第6周采集母乳样本（n = 769）。通过高分辨率毛细管气液色谱法测定母乳样本的脂肪酸组成。
反式十八碳烯酸和反式十八碳二烯酸与亚油酸（r = -0.32和-0.33，两者P均<0.0001）、α-亚麻酸（r = -0.35和-0.27，P<0.0001）、花生四烯酸（r = -0.60和-0.47，P<0.0001）以及二十二碳六烯酸（r = -0.51和-0.33，P<0.0001）呈负相关。相比之下，反式十六碳烯酸与多不饱和脂肪酸之间未观察到负相关。
本研究获得的数据表明，18碳反式异构脂肪酸的含量可能与成熟母乳中长链多不饱和脂肪酸的含量呈负相关。
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