Flensborg-Madsen Trine, Knop Joachim, Mortensen Erik Lykke, Becker Ulrik, Grønbaek Morten
Institute of Preventive Medicine, Copenhagen University Hospital, Centre for Health and Society, Denmark.
Alcohol Alcohol. 2007 Sep-Oct;42(5):442-7. doi: 10.1093/alcalc/agm033. Epub 2007 May 9.
It is generally accepted, but not yet documented that the risk of future alcoholism increases with the amount of alcohol consumed. The objective of this study was to investigate this association using the Copenhagen City Heart Study.
Quantity and frequency of alcohol intake was measured in 19 698 men and women randomly drawn from the Copenhagen Population Register in 1976-78. The study population was linked to three different registers in order to detect alcoholism, and average follow-up time was 25 years.
After adjustment for all putative confounders, the risk of alcoholism for women increased significantly at 1-7 drinks per week with a hazard ratio (HR) of 2.02 (95% confidence interval (CI): 1.16, 3.53) compared to never/almost never drinking; the HR for drinking monthly was 1.75 (95% CI: 1.08, 2.85). The risk for men did not increase significantly before 22-41 drinks per week (HR = 3.81, 95 % CI: 2.18, 6.68) or if they had a daily alcohol intake (HR = 3.55, 95 % CI: 2.11, 5.99). Smoking was independently associated with the risk of alcoholism for both men and women.
The risk of developing alcoholism increased significantly by very low intakes of alcohol in women, while the risk is only increased significantly in men consuming more than 21 drinks per week.
人们普遍认为，未来酗酒的风险会随着酒精摄入量的增加而上升，但尚未有文献记载。本研究的目的是利用哥本哈根城市心脏研究来调查这种关联。
1976 - 1978年，从哥本哈根人口登记册中随机抽取了19698名男性和女性，测量他们的酒精摄入量和饮酒频率。为了检测酗酒情况，将研究人群与三个不同的登记册进行关联，平均随访时间为25年。
在对所有假定的混杂因素进行调整后，与从不/几乎不饮酒相比，女性每周饮用1 - 7杯酒时，酗酒风险显著增加，风险比（HR）为2.02（95%置信区间（CI）：1.16，3.53）；每月饮酒的HR为1.75（95% CI：1.08，2.85）。男性每周饮用22 - 41杯酒之前，酗酒风险没有显著增加（HR = 3.81，95% CI：2.18，6.68），或者如果他们每日饮酒，酗酒风险也没有显著增加（HR = 3.55，95% CI：2.11，5.99）。吸烟与男性和女性的酗酒风险均独立相关。
女性即使摄入极低量的酒精，患酗酒症的风险也会显著增加，而男性只有在每周饮酒超过21杯时，患酗酒症的风险才会显著增加。
