Mørch Lina S, Johansen Ditte, Thygesen Lau C, Tjønneland Anne, Løkkegaard Ellen, Stahlberg Claudia, Grønbaek Morten
Centre for Alcohol Research, National Institute of Public Health, Copenhagen, Denmark.
Eur J Public Health. 2007 Dec;17(6):624-9. doi: 10.1093/eurpub/ckm036. Epub 2007 Apr 18.
The aim of this study was to analyse the impact of alcohol intake and drinking pattern on the risk of breast cancer.
A total of 17 647 nurses were followed from 1993 until the end of 2001. At baseline participants completed a questionnaire on alcohol intake and other lifestyle-related factors. Data were analysed using Cox's proportional hazard model.
During follow-up 457 women were diagnosed with breast cancer. The relative risk of breast cancer was 2.30 [Confidence interval (CI): 1.56-3.39] for alcohol intake of 22-27 drinks per week, compared to 1-3 drinks per week. Among alcohol consumers, weekly alcohol intake increased the risk of breast cancer with 2% for each additional drink consumed. Weekend consumption increased the risk with 4% for each additional drink consumed friday through sunday. Binge drinking of 4-5 drinks the latest weekday increased risk with 55%, compared with consumption of one drink. A possible threshold in risk estimates was found for consumption above 27 drinks per week.
For alcohol consumption above the intake most frequently reported, the risk of breast cancer is increased. The risk is minor for moderate levels but increases for each additional drink consumed during the week. Weekend consumption and binge drinking imply an additional increase in breast cancer risk.
本研究旨在分析饮酒量和饮酒模式对乳腺癌风险的影响。
对17647名护士从1993年至2001年底进行随访。在基线时，参与者完成了一份关于饮酒量和其他生活方式相关因素的问卷。使用Cox比例风险模型对数据进行分析。
在随访期间，457名女性被诊断患有乳腺癌。每周饮酒22 - 27杯的女性患乳腺癌的相对风险为2.30 [置信区间(CI)：1.56 - 3.39]，而每周饮酒1 - 3杯的女性相对风险为1。在饮酒者中，每周饮酒量每增加一杯，患乳腺癌的风险增加2%。周末饮酒时，周五至周日期间每多喝一杯，患癌风险增加4%。与饮用一杯酒相比，在工作日最近一次狂饮4 - 5杯会使风险增加55%。每周饮酒超过27杯时，风险估计中发现了一个可能的阈值。
对于高于最常报告饮酒量的饮酒情况，患乳腺癌的风险会增加。适度饮酒时风险较小，但每周每多喝一杯风险就会增加。周末饮酒和狂饮意味着患乳腺癌风险会进一步增加。
