Kelekci Sefa, Uygur Dilek, Yilmaz Bulent, Sut Necdet, Yesildaglar Narter
Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
Arch Gynecol Obstet. 2007 Oct;276(4):355-9. doi: 10.1007/s00404-007-0376-7. Epub 2007 May 10.
To investigate the effectiveness of human amniotic membrane (HAM) in the prevention of postoperative adhesion formation and to compare it with the efficacy of hyaluronate/carboxymethylcellulose (HA/CMC) membrane in a rat model.
Following pilot studies and computer-generated randomization, 23 female Wistar albino rats were operated on in the full study. One of the uterine horns with standard lesions was treated with either HAM (n = 13) or HA/CMC (n = 10) and the other uterine horn served as the control. Second look laparotomies were performed 2 weeks after the operations. Main outcome measures were extent, severity, degree, total adhesion scores and histopathologic characteristics of adhesions.
Uterine horns treated with HAM had significantly lower total adhesion scores than the controls (5.15 +/- 2.67 vs. 7.92 +/- 1.50, P < 0.05). Total adhesion scores of uterine horns treated with HA/CMC membrane were significantly lower than those of the controls (4.30 +/- 1.95 vs. 7.50 +/- 1.84, P < 0.01). There were no significant differences between the HAM and HA/CMC groups regarding any adhesion scores.
HAM and HA/CMC membrane are both effective for prevention of adhesion formation in a rat uterine horn model; however, one does not seem to be more effective than the other.
在大鼠模型中研究人羊膜（HAM）预防术后粘连形成的有效性，并将其与透明质酸盐/羧甲基纤维素（HA/CMC）膜的疗效进行比较。
在进行初步研究并通过计算机生成随机分组后，23只雌性Wistar白化大鼠纳入完整研究。将一侧有标准损伤的子宫角用HAM（n = 13）或HA/CMC（n = 10）处理，另一侧子宫角作为对照。术后2周进行二次剖腹探查。主要观察指标为粘连的范围、严重程度、程度、总粘连评分及组织病理学特征。
用HAM处理的子宫角总粘连评分显著低于对照组（5.15±2.67对7.92±1.50，P < 0.05）。用HA/CMC膜处理的子宫角总粘连评分显著低于对照组（4.30±1.95对7.50±1.84，P < 0.01）。在任何粘连评分方面，HAM组和HA/CMC组之间均无显著差异。
在大鼠子宫角模型中，HAM和HA/CMC膜对预防粘连形成均有效；然而，两者似乎效果相当。
