Kang Byung Wan, Lee Hyo Seok, Oh Han Jin, Yoon Kyung Chul
Department of Ophthalmology, Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, Gwangju, Korea.
Chonnam Med J. 2012 Aug;48(2):123-7. doi: 10.4068/cmj.2012.48.2.123. Epub 2012 Aug 24.
This study aimed to evaluate the anti-adhesive effect of a mixed solution of sodium hyaluronate and sodium carboxymethylcellulose (HACMC, Guardix-sol®) during the transconjunctival approach to orbital wall reconstruction. Eighty-seven patients who underwent orbital wall reconstruction by the transconjunctival approach were enrolled in this prospective study. We applied HACMC between the orbicularis oculi muscle and the orbital septum after surgery in 47 patients and did not use it in 40 patients. Lower lid retraction and marginal reflex distance 2 (MRD(2)) were measured to analyze the degree of postoperative adhesion at 1 week and 1, 3, and 6 months. The degree of MRD(2) showed clinically significant differences at postoperative 1 week and 1 month between the HACMC and control groups (p<0.05). Lower lid ectropion developed in two patients (5.0%) in the control group but did not occur in the HACMC group. In orbital wall reconstruction by the transconjunctival approach, the HACMC mixture solution is effective for preventing adhesion and lower lid ectropion during the early postoperative period.
本研究旨在评估透明质酸钠和羧甲基纤维素钠混合溶液（HACMC，Guardix-sol®）在经结膜入路眶壁重建术中的抗粘连效果。87例行经结膜入路眶壁重建术的患者纳入了这项前瞻性研究。我们在术后对47例患者在眼轮匝肌和眶隔之间应用了HACMC，而40例患者未使用。测量下睑退缩和边缘反射距离2（MRD(2)）以分析术后1周、1个月、3个月和6个月时的粘连程度。HACMC组和对照组术后1周和1个月时MRD(2)程度显示出临床显著差异（p<0.05）。对照组有2例患者（5.0%）出现下睑外翻，而HACMC组未发生。在经结膜入路眶壁重建术中，HACMC混合溶液在术后早期对预防粘连和下睑外翻有效。
