Cinatl Jindrich, Michaelis Martin, Doerr Hans W
Institute for Medical Virology, Hospital of the Johann Wolfgang Goethe University, Paul-Ehrlich-Str. 40, 60596, Frankfurt/M, Germany.
Med Microbiol Immunol. 2007 Dec;196(4):181-90. doi: 10.1007/s00430-007-0042-5. Epub 2007 Mar 20.
Among emerging and re-emerging infectious diseases, influenza constitutes one of the major threats to mankind. In this review series epidemiologic, virologic and pathologic concerns raised by infections of humans with avian influenza virus A/H5N1 are discussed. This first part concentrates on epidemiologic concerns and virulence determinants. H5N1 spread over the world and caused a series of fowl pest outbreaks. Significant human-to-human transmissions have not been observed yet. Mutations that make the virus more compatible with human-to-human transmission may occur at any time. Nevertheless, no one can currently predict with certainty whether H5N1 will become a human pandemic virus.
在新出现和再次出现的传染病中，流感是对人类的主要威胁之一。在本综述系列中，将讨论人类感染甲型H5N1禽流感病毒引发的流行病学、病毒学和病理学问题。第一部分着重于流行病学问题和毒力决定因素。H5N1在全球传播并引发了一系列家禽疫情。尚未观察到明显的人传人情况。使该病毒更易于人传人的突变可能随时发生。然而，目前没有人能够确切预测H5N1是否会成为一种能引发全球大流行的人类病毒。
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