Oner Ahmet Faik, Bay Ali, Arslan Sukru, Akdeniz Hayrettin, Sahin Huseyin Avni, Cesur Yasar, Epcacan Serdar, Yilmaz Neziha, Deger Ibrahim, Kizilyildiz Baran, Karsen Hasan, Ceyhan Mehmet
Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
N Engl J Med. 2006 Nov 23;355(21):2179-85. doi: 10.1056/NEJMoa060601.
An outbreak of highly pathogenic avian influenza A (H5N1) that had previously been detected throughout Asia, with major economic and health repercussions, extended to eastern Turkey in late December 2005 and early January 2006.
We documented the epidemiologic, clinical, and radiologic features of all cases of confirmed H5N1 virus infection in patients who were admitted to Yuzuncu Yil University Hospital in Van, Turkey, between December 31, 2005, and January 10, 2006.
H5N1 virus infection was diagnosed in eight patients. The patients were 5 to 15 years of age, and all eight had a history of close contact with diseased or dead chickens. The mean (+/-SD) time between exposure and the onset of illness was 5.0+/-1.3 days. All the patients had fever, and seven had clinical and radiologic evidence of pneumonia at presentation; four patients died. Results of enzyme-linked immunosorbent assay and rapid influenza tests were negative in all patients, and the diagnosis was made by means of a polymerase-chain-reaction assay.
H5N1, which causes a spectrum of illnesses in humans, including severe and fatal respiratory disease, can be difficult to diagnose.
高致病性甲型禽流感（H5N1）疫情此前已在亚洲各地被发现，造成了重大经济和健康影响，于2005年12月底和2006年1月初蔓延至土耳其东部。
我们记录了2005年12月31日至2006年1月10日期间收治于土耳其凡城尤祖恩居尔大学医院的所有确诊H5N1病毒感染患者的流行病学、临床和放射学特征。
8例患者被诊断为H5N1病毒感染。患者年龄在5至15岁之间，所有8例患者均有与患病或死亡鸡只密切接触史。暴露至发病的平均（±标准差）时间为5.0±1.3天。所有患者均有发热症状，7例患者就诊时具有临床和放射学肺炎证据；4例患者死亡。所有患者的酶联免疫吸附测定和快速流感检测结果均为阴性，诊断通过聚合酶链反应测定法做出。
H5N1可导致人类一系列疾病，包括严重和致命的呼吸道疾病，可能难以诊断。
