Gardner Julie L, Craven Lyndsey, Turnbull Douglass M, Taylor Robert W
Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Biosci Rep. 2007 Jun;27(1-3):139-50. doi: 10.1007/s10540-007-9042-3.
An extensive range of molecular defects have been identified in the human mitochondrial genome (mtDNA), causing a range of clinical phenotypes characterized by mitochondrial respiratory chain dysfunction. Sadly, given the complexities of mitochondrial genetics, there are no available cures for mtDNA disorders. In this review, we consider experimental, genetic-based strategies that have been or are being explored towards developing treatments, focussing on two specific areas which we are actively pursuing--assessing the benefit of exercise training for patients with mtDNA defects, and the prevention of mtDNA disease transmission.
人类线粒体基因组（mtDNA）中已发现广泛的分子缺陷，这些缺陷导致一系列以线粒体呼吸链功能障碍为特征的临床表型。遗憾的是，鉴于线粒体遗传学的复杂性，目前尚无治疗线粒体DNA疾病的方法。在这篇综述中，我们考虑了已经或正在探索的基于实验和遗传学的治疗策略，重点关注我们正在积极研究的两个特定领域——评估运动训练对线粒体DNA缺陷患者的益处，以及预防线粒体DNA疾病的传播。
