脑脊液神经丝轻链蛋白浓度升高可预测艾滋病痴呆综合征的发生。

Elevated cerebrospinal fluid neurofilament light protein concentrations predict the development of AIDS dementia complex.

作者信息

Gisslen Magnus, Hagberg Lars, Brew Bruce J, Cinque Paola, Price Richard W, Rosengren Lars

机构信息

Department of Infectious Diseases, The Sahlgrenska Academy at Goteborg University, Goteborg, SE-416 85, Sweden, and Department of Neurology, St. Vincent's Hospital, Sydney, NSW, Australia.

出版信息

J Infect Dis. 2007 Jun 15;195(12):1774-8. doi: 10.1086/518043. Epub 2007 May 2.

DOI:10.1086/518043

PMID:17492593

Abstract

The light subunit of neurofilament protein (NFL) is a sensitive indicator of central nervous system axonal injury. We retrospectively identified 9 subjects participating in a longitudinal cohort study who developed acquired immunodeficiency syndrome dementia complex (ADC) and who had had a lumbar puncture performed within 2 years before presentation. Elevated cerebrospinal fluid (CSF) NFL concentrations were found in 7 (78%) of the 9 case patients who later developed ADC, compared with 9 (33%) of 27 CD4 cell count-matched HIV-1-infected control subjects. By contrast, no differences were found in CSF HIV-1 RNA or neopterin concentrations between the 2 groups. CSF NFL may prove to be a useful predictive marker for ADC.

摘要

神经丝蛋白（NFL）的轻链亚基是中枢神经系统轴突损伤的敏感指标。我们回顾性地确定了9名参与纵向队列研究的受试者，他们患上了获得性免疫缺陷综合征痴呆综合征（ADC），并且在就诊前2年内进行过腰椎穿刺。在后来患上ADC的9例患者中，有7例（78%）脑脊液（CSF）NFL浓度升高，相比之下，在27例CD4细胞计数匹配的HIV-1感染对照受试者中，有9例（33%）升高。相比之下，两组之间的脑脊液HIV-1 RNA或蝶呤浓度没有差异。脑脊液NFL可能被证明是ADC的一种有用的预测标志物。