Jokanović L, Cvrtila D, Klarić P, Kanajet D
Klinicka bolnica Sestre milosrdnice, Klinika za zenske bolesti i porodiljstvo.
Jugosl Ginekol Perinatol. 1991 May-Aug;31(3-4):49-51.
In a prospective study conducted from 1981 to 1989, concentrations of estrogen (ER) and progesterone (PR) receptors were determined by the saturation analysis of cytosols prepared from 67 samples of human endometrial tissue. Patients over 35 years of age who had come to the hospital because of irregular bleeding were included in the investigation. In the group examined it was found that 25 patients developed endometrial carcinoma, 22 hyperplasia adenomatosa and 20 patients had normal pathohistological findings. The median values of ER concentrations were 46, 99 and 31 fmol/mg of protein, with the ranges of 0-628, 0-2348 and 0-552 fmole/mg of protein in the group with normal endometrial tissue, hyperplastically transformed endometrial tissue and in the group with endometrial carcinoma, respectively. The median values of PR concentrations were 196, 307 and 96 fmol/mg of protein, with the ranges of 0-1714, 0-2402 and 0-582 fmole/mg of protein in the group with normal endometrial tissue, hyperplastically transformed endometrial tissue and in the group with endometrial carcinoma, respectively. In the group of patients with endometrial carcinoma 40% of ER+/PR+ tumors (greater than 50 fmole/mg of protein), 36% of ER-/PR-tumors, and 24% of ER-/PR+ tumors were found. The results of the median test showed that there were no statistically significant differences among ER concentrations (chi 2 = 2.822; P = 0.2439), or among PR concentrations (chi 2 = 3.582; P = 0.1668) in the groups of patients examined.
在1981年至1989年进行的一项前瞻性研究中，通过对67份人类子宫内膜组织样本制备的胞质溶胶进行饱和分析，测定了雌激素（ER）和孕激素（PR）受体的浓度。纳入研究的患者为35岁以上因不规则出血前来医院就诊的患者。在所检查的组中，发现25例患者发生子宫内膜癌，22例为腺瘤样增生，20例患者病理组织学检查结果正常。正常子宫内膜组织组、增生性转化子宫内膜组织组和子宫内膜癌组中ER浓度的中位数分别为46、99和31 fmol/mg蛋白质，范围分别为0 - 628、0 - 2348和0 - 552 fmole/mg蛋白质。正常子宫内膜组织组、增生性转化子宫内膜组织组和子宫内膜癌组中PR浓度的中位数分别为196、307和96 fmol/mg蛋白质，范围分别为0 - 1714、0 - 2402和0 - 582 fmole/mg蛋白质。在子宫内膜癌患者组中，发现40%的肿瘤为ER+/PR+（大于50 fmole/mg蛋白质），36%为ER - /PR - 肿瘤，24%为ER - /PR+肿瘤。中位数检验结果显示，在所检查的患者组中，ER浓度之间（χ2 = 2.822；P = 0.2439）或PR浓度之间（χ2 = 3.582；P = 0.1668）无统计学显著差异。
