Sjåheim Tone, Kongerud Johny, Søyseth Vidar
Department of Respiratory Medicine, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway.
Am J Ind Med. 2007 Jun;50(6):443-8. doi: 10.1002/ajim.20464.
Aluminum potroom asthma (PA) has been described in several reports. This study aimed to investigate the association between blood eosinophils and PA.
In a cross-sectional study, 338 workers were examined as follows: spirometry, blood eosinophils, skin prick test, and work exposure measurements. They also completed a questionnaire on respiratory symptoms, smoking, allergy, and duration of work exposure.
The odds ratio for PA was 4.2 (95% confidence interval 1.5-9.7) for workers with eosinophils > or =400 x 10(6) cells/L compared with workers with eosinophils <200 x 10(6) cells/L. In non-smokers, the number of eosinophils was 177 x 10(6) cells/L (P < 0.001) higher among workers with PA than asymptomatic workers, whereas the corresponding difference among current smokers was only 63 x 10(6) cells/L (P = 0.03).
The prevalence of PA was positively associated with blood eosinophils. An attenuation of the blood eosinophil increase was observed in smoking asthmatics, suggesting an immune-modulating effect of smoking.
已有多篇报道描述了铝电解车间哮喘（PA）。本研究旨在调查血液嗜酸性粒细胞与PA之间的关联。
在一项横断面研究中，对338名工人进行了如下检查：肺功能测定、血液嗜酸性粒细胞检测、皮肤点刺试验和工作场所暴露测量。他们还完成了一份关于呼吸道症状、吸烟、过敏和工作暴露时长的问卷。
与嗜酸性粒细胞<200×10⁶个/升的工人相比，嗜酸性粒细胞≥400×10⁶个/升的工人患PA的比值比为4.2（95%置信区间1.5 - 9.7）。在不吸烟者中，患PA的工人血液嗜酸性粒细胞数量比无症状工人高177×10⁶个/升（P < 0.001），而当前吸烟者之间的相应差异仅为63×10⁶个/升（P = 0.03）。
PA的患病率与血液嗜酸性粒细胞呈正相关。在吸烟哮喘患者中观察到血液嗜酸性粒细胞增加有所减弱，提示吸烟具有免疫调节作用。
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