Hillhouse Maureen P, Marinelli-Casey Patricia, Gonzales Rachel, Ang Alfonso, Rawson Richard A
University of California, Los Angeles, Semel Neuropsychiatric Institute, CA, USA.
Addiction. 2007 Apr;102 Suppl 1:84-95. doi: 10.1111/j.1360-0443.2007.01768.x.
This study examines the utility of individual drug use and treatment characteristics for predicting in-treatment performance and post-treatment outcomes over a 1-year period.
DESIGN, SETTING AND PARTICIPANTS: Data were collected from 420 adults who participated in the Methamphetamine Treatment Project (MTP), a multi-site study of randomly assigned treatment for methamphetamine dependence. Interviews were conducted at baseline, during treatment and during three follow-up time-points: treatment discharge and at 6 and 12 months following admission.
The Addiction Severity Index (ASI); the Craving, Frequency, Intensity and Duration Estimate (CFIDE); and laboratory urinalysis results were used in the current study.
Analyses addressed both in-treatment performance and post-treatment outcomes. The most consistent finding is that pre-treatment methamphetamine use predicts in-treatment performance and post-treatment outcomes. No one variable predicted all in-treatment performance measures; however, gender, route of administration and pre-treatment methamphetamine use were significant predictors. Similarly, post-treatment outcomes were predicted by a range of variables, although pre-treatment methamphetamine use was significantly associated with each post-treatment outcome.
These findings provide useful empirical information about treatment outcomes for methamphetamine abusers, and highlight the utility of assessing individual and in-treatment characteristics in the development of appropriate treatment plans.
本研究探讨个体药物使用情况及治疗特征在预测一年期治疗期间表现和治疗后结果方面的效用。
设计、地点和参与者:数据收集自420名参与甲基苯丙胺治疗项目(MTP)的成年人,该项目是一项针对甲基苯丙胺依赖的随机分配治疗的多地点研究。在基线、治疗期间以及三个随访时间点进行访谈:治疗出院时以及入院后6个月和12个月。
本研究使用了成瘾严重程度指数(ASI)、渴望、频率、强度和持续时间估计(CFIDE)以及实验室尿液分析结果。
分析涉及治疗期间表现和治疗后结果。最一致的发现是治疗前甲基苯丙胺使用情况可预测治疗期间表现和治疗后结果。没有一个变量能预测所有治疗期间表现指标;然而,性别、给药途径和治疗前甲基苯丙胺使用情况是显著预测因素。同样,一系列变量可预测治疗后结果,尽管治疗前甲基苯丙胺使用情况与每个治疗后结果均显著相关。
这些发现为甲基苯丙胺滥用者的治疗结果提供了有用的实证信息,并突出了在制定适当治疗计划时评估个体和治疗期间特征的效用。