[伴有血细胞减少症的格雷夫斯病患者的淋巴细胞变化]
[Lymphocyte changes in patients with Graves's disease accompanied by hematocytopenia].
作者信息
Zhang Hai-Yan, Li Yu-Fang
机构信息
Department of Hematology, Linyi Municipal People Hospital, Linyi 276003, China.
出版信息
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Apr;15(2):429-32.
The aim of study was to investigate the lymphocyte changes in peripheral blood of patients with Graves's disease accompanied by hematocytopenia and to explore its pathogenesis. The quantity and ratio of Th(2), Th(1), CD5(+) B, Bcl-2 level in 24 Graves's disease patients with hematocytopenia were detected by FACS, and 18 adults were selected as normal controls. The results indicated that the percentages of Th(1), Th(2), ratio of Th(2)/Th(1), CD5(+) B, Bcl-2 level in peripheral blood of the patients were (0.81 +/- 0.45)%, (6.83 +/- 3.02)%, (20.55 +/- 6.15)%, (20.89 +/- 1.62)%, (80.25 +/- 15.56)%, respectively, and were higher than those of normal controls [(0.39 +/- 0.24)% (P<0.05), (0.28 +/- 0.15)% (P<0.01), (0.52 +/- 0.12)% (P<0.01), (7.89 +/- 0.38)% (P<0.05), (36.49 +/- 6.79)% (P<0.05)]. It is concluded that the pathogenesis of Graves's disease with hematocytopenia may be related to unbalance of Th(1)/Th(2), increase of Th(2) inducing over-expression of CD5(+) B and Bcl-2 on B cell.
本研究旨在探讨格雷夫斯病（Graves's disease）伴血细胞减少患者外周血淋巴细胞的变化，并探讨其发病机制。采用流式细胞术检测24例格雷夫斯病伴血细胞减少患者外周血中Th(2)、Th(1)、CD5(+) B细胞数量及比例、Bcl-2水平，并选取18例健康成人作为正常对照。结果显示，患者外周血中Th(1)、Th(2)细胞百分比、Th(2)/Th(1)比值、CD5(+) B细胞数量及Bcl-2水平分别为(0.81±0.45)%、(6.83±3.02)%、(20.55±6.15)%、(20.89±1.62)%、(80.25±15.56)%，均高于正常对照组[(0.39±0.24)%(P<0.05)、(0.28±0.15)%(P<0.01)、(0.52±0.12)%(P<0.01)、(7.89±0.38)%(P<0.05)、(36.49±6.79)%(P<0.05)]。结论：格雷夫斯病伴血细胞减少的发病机制可能与Th(1)/Th(2)失衡、Th(2)增多诱导B细胞CD5(+) B及Bcl-2过度表达有关。
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