Aflatoonian Reza, Fazeli Alireza
Academic Unit of Reproductive and Developmental Medicine, The University of Sheffield, Level 4, Jessop Wing, Tree Root Walk, Sheffield, UK.
J Reprod Immunol. 2008 Jan;77(1):7-13. doi: 10.1016/j.jri.2007.03.014. Epub 2007 May 9.
Rapid innate immune defences against infection usually involve the recognition of invading pathogens by specific pattern recognition receptors recently attributed to the family of Toll-like receptors (TLR). TLRs constitute a major part of innate immune system, and have been characterised in different tissues and organs. Reports from our laboratory and others have demonstrated the existence of TLRs in the female reproductive tract, yet TLRs have not been explored completely in this system. There is little known about variation in TLR expression during the menstrual cycle and the effects that sex hormones may have on their expression and function. Here, we review recent information regarding the existence of TLRs in the female reproductive tract, their function in the maintenance of innate immune system in this tract and their potential role in pregnancy.
针对感染的快速先天性免疫防御通常涉及特定模式识别受体对入侵病原体的识别，这些受体最近被归为Toll样受体（TLR）家族。TLR是先天性免疫系统的主要组成部分，已在不同组织和器官中得到表征。我们实验室和其他机构的报告已证明女性生殖道中存在TLR，但该系统中的TLR尚未得到充分研究。关于月经周期中TLR表达的变化以及性激素可能对其表达和功能产生的影响，目前知之甚少。在此，我们综述了有关女性生殖道中TLR的存在、其在维持该生殖道先天性免疫系统中的功能以及它们在妊娠中的潜在作用的最新信息。
