Sentman Charles L, Wira Charles R, Eriksson Mikael
Department of Microbiology & Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA.
Am J Reprod Immunol. 2007 Feb;57(2):108-15. doi: 10.1111/j.1600-0897.2006.00448.x.
Uterine NK cells have a unique phenotype compared with blood NK cell subsets, yet little is known about how NK cells function as a part of the innate immune cell network in the female reproductive tract.
The expression of key receptors and function of uterine NK cells in response to cytokines, sex hormones, and pathogen associated molecular patterns (PAMPs) was analyzed. This article summarizes recent findings on the biology and function of NK cells in the female reproductive tract.
Uterine NK cells express Toll-like receptors and respond to cytokines and PAMPs under specific conditions. Evidence indicates that NK cells play an important role in the reorganization of blood vessels during pregnancy.
Human uterine NK cells are a major population of leukocytes in the endometrium and play an important role as a component of host defense and in successful reproduction.
与血液中的自然杀伤细胞亚群相比，子宫自然杀伤细胞具有独特的表型，但对于自然杀伤细胞作为女性生殖道固有免疫细胞网络的一部分如何发挥作用，人们知之甚少。
分析了子宫自然杀伤细胞关键受体的表达以及其对细胞因子、性激素和病原体相关分子模式（PAMPs）的反应功能。本文总结了关于女性生殖道中自然杀伤细胞生物学和功能的最新研究结果。
子宫自然杀伤细胞表达Toll样受体，并在特定条件下对细胞因子和PAMPs作出反应。有证据表明，自然杀伤细胞在孕期血管重塑中发挥重要作用。
人类子宫自然杀伤细胞是子宫内膜中白细胞的主要群体，作为宿主防御的组成部分以及在成功受孕过程中发挥重要作用。
