Billeter Sarah A, Spencer Jennifer A, Griffin Brenda, Dykstra Christine C, Blagburn Byron L
Department of Pathobiology, 166 Greene Hall, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, United States.
Vet Parasitol. 2007 Jun 20;147(1-2):194-8. doi: 10.1016/j.vetpar.2007.03.028. Epub 2007 May 9.
Anaplasma phagocytophilum is among the more common tick-borne disease agents in the United States. It is of veterinary and public health significance as dogs, cats, and human beings are known to be susceptible. A. phagocytophilum is transmitted trans-stadially by either nymphs or adults of either the black-legged tick (Ixodes scapularis) or the western black-legged tick (Ixodes pacificus). Little information is available regarding either the prevalence of this agent in cats or the dynamics of vector transmission. Four hundred and sixty feline blood samples from sites throughout the United States were assayed for antibodies to A. phagocytophilum using an indirect immunofluorescence assay (IFA). Results of the prevalence study showed that 20 samples (4.3%) were positive for A. phagocytophilum antibodies by IFA at a 1:50 dilution, however these results could not be confirmed by PCR analysis. PCR analysis for other cross-reacting Ehrlichia/Anaplasma spp. was also negative. These results demonstrate that natural infection of A. phagocytophilum in cats is uncommon.
嗜吞噬细胞无形体是美国较为常见的蜱传疾病病原体之一。由于已知狗、猫和人类都易感染，它具有兽医和公共卫生意义。嗜吞噬细胞无形体可通过黑腿蜱（肩突硬蜱）或西部黑腿蜱（太平洋硬蜱）的若虫或成虫经变态期传播。关于该病原体在猫中的流行情况或媒介传播动态的信息很少。使用间接免疫荧光法（IFA）对来自美国各地的460份猫血样进行了嗜吞噬细胞无形体抗体检测。患病率研究结果显示，在1:50稀释度下，有20份样本（4.3%）通过IFA检测出嗜吞噬细胞无形体抗体呈阳性，但这些结果无法通过PCR分析得到证实。对其他交叉反应性埃立克体/无形体属的PCR分析也为阴性。这些结果表明，猫自然感染嗜吞噬细胞无形体并不常见。
