Pelkey Kenneth A, McBain Chris J
Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Building 35, Bethesda, MD 20892, USA.
Curr Opin Neurobiol. 2007 Jun;17(3):366-73. doi: 10.1016/j.conb.2007.04.008. Epub 2007 May 9.
Information transfer within neuronal networks requires the precise coordination of distinct neuronal populations within a given circuit. Evidence from a variety of central pathways indicates that such coordination is mediated in part by the ability of neurons to differentially regulate release properties at functionally divergent presynaptic elements along their individual axons according to the identity of the postsynaptic cell being innervated. Recent findings have revealed the cellular mechanisms by which central afferents modify release properties at individual presynaptic sites independent of neighboring terminals. Such autonomy of presynaptic regulation enables target-cell-dependent short-term and long-term synaptic plasticity and ensures that distinct features of afferent activity are relayed to divergent target-cell populations.
神经网络内的信息传递需要给定回路中不同神经元群体的精确协调。来自各种中枢通路的证据表明，这种协调部分是由神经元根据所支配的突触后细胞的身份，在其各自轴突上功能不同的突触前元件处差异性调节释放特性的能力介导的。最近的研究结果揭示了中枢传入神经独立于相邻终末在单个突触前位点改变释放特性的细胞机制。这种突触前调节的自主性实现了依赖靶细胞的短期和长期突触可塑性，并确保传入活动的不同特征被传递到不同的靶细胞群体。
