Nademanee K
Cardiology Division, Denver General Hospital, CO 80204-4507.
NIDA Res Monogr. 1991;108:116-20.
The finding that most young cocaine addict patients had a negative exercise treadmill test suggests that they did not have preexisting obstructive coronary artery disease. Noninvasive testing did show, however, that these patients frequently had a high incidence of ST elevation episodes during the first 2 weeks of withdrawal. The pathophysiological mechanism of cocaine-induced cardiovascular disease is not yet clearly understood, but it is probably more complex than the drug's acute direct effects on the cardiovascular system. It may be complicated by fluctuations in catecholamine homeostasis and further temporally complicated by cycles of cocaine use and withdrawal. Research on how cocaine use alters catecholamine homeostasis will increase the understanding of the pathophysiology of cocaine and assist in developing effective pharmacologic and prophylactic treatment for its abuse.
大多数年轻可卡因成瘾患者运动平板试验结果为阴性，这一发现表明他们不存在预先存在的阻塞性冠状动脉疾病。然而，无创检测确实显示，这些患者在戒断的前两周内经常出现ST段抬高发作的高发生率。可卡因诱发心血管疾病的病理生理机制尚未完全清楚，但可能比该药物对心血管系统的急性直接作用更为复杂。它可能因儿茶酚胺稳态的波动而复杂化，并且在时间上因可卡因使用和戒断的周期而进一步复杂化。关于可卡因使用如何改变儿茶酚胺稳态的研究将增进对可卡因病理生理学的理解，并有助于开发针对其滥用的有效药物和预防性治疗方法。
