van der Goot J A, van Boven M, de Jong M C M, Koch G
Central Institute for Animal Disease Control Lelystad, Houtribweg 39, 8221 RA Lelystad, The Netherlands.
Avian Dis. 2007 Mar;51(1 Suppl):323-4. doi: 10.1637/7658-060206R.1.
The highly pathogenic H5N1 avian influenza virus is widespread among domestic ducks throughout Southeast Asia. Many aspects of the poultry industry and social habits hinder the containment and eradication of AI. Vaccination is often put forward as a tool for the control of AI. However, vaccination will only lead to eradication when it reduces the virus spread to such an extent that herd immunity is obtained. To study the effect of a single vaccination dose on the transmission of H5N1 in domestic ducks we performed experiments in which infected and uninfected ducks were housed together and the infection chain was monitored by means of virus isolation and serology. Specifically, Peking ducks were vaccinated with A/Chicken/Mexico/232/94/ CPA H5N2 and challenged with A/Chicken/GxLA/1204/04 H5N1 one week after vaccination. In both the control and vaccinated groups all inoculated and contact animals were quickly infected. However, the disease signs and mortality differed between the control and treatment groups. This finding may have important implications for the control of H5N1 by means of vaccination.
高致病性H5N1禽流感病毒在东南亚的家鸭中广泛传播。家禽业和社会习惯的许多方面阻碍了禽流感的控制和根除。疫苗接种常被作为控制禽流感的一种手段。然而，只有当疫苗接种将病毒传播降低到获得群体免疫的程度时，才会导致根除。为了研究单剂量疫苗接种对H5N1在家鸭中传播的影响，我们进行了实验，将感染和未感染的鸭子放在一起饲养，并通过病毒分离和血清学监测感染链。具体而言，用A/Chicken/Mexico/232/94/CPA H5N2对北京鸭进行疫苗接种，并在接种一周后用A/Chicken/GxLA/1204/04 H5N1进行攻毒。在对照组和疫苗接种组中，所有接种和接触的动物都很快被感染。然而，对照组和治疗组之间的疾病症状和死亡率有所不同。这一发现可能对通过疫苗接种控制H5N1具有重要意义。
