Singla Sheela, Kreitzer Anatol C, Malenka Robert C
Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304, USA.
J Neurosci. 2007 May 9;27(19):5260-4. doi: 10.1523/JNEUROSCI.0018-07.2007.
Endocannabinoid (eCB)-mediated forms of long-term synaptic plasticity occur in several brain regions, but much remains unknown about their basic properties and underlying mechanisms. Here, we present evidence that eCB-mediated long-term depression (eCB-LTD) at excitatory synapses on medium spiny neurons in the striatum requires presynaptic activity coincident with CB1 receptor activation. This dual requirement for CB1 activation and presynaptic activity is a mechanism by which eCB-LTD may be made synapse specific.
内源性大麻素(eCB)介导的长期突触可塑性形式存在于多个脑区,但关于其基本特性和潜在机制仍有许多未知之处。在这里,我们提供证据表明,纹状体中等棘状神经元兴奋性突触处的eCB介导的长期抑制(eCB-LTD)需要与CB1受体激活同时发生的突触前活动。对CB1激活和突触前活动的这种双重要求是一种机制,通过该机制eCB-LTD可以具有突触特异性。