Mueller-Mang Christina, Grosse Claudia, Schmid Katharina, Stiebellehner Leopold, Bankier Alexander A
Department of Radiology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
Radiographics. 2007 May-Jun;27(3):595-615. doi: 10.1148/rg.273065130.
The American Thoracic Society-European Respiratory Society classification of idiopathic interstitial pneumonias (IIPs), published in 2002, defines the morphologic patterns on which clinical-radiologic-pathologic diagnosis of IIPs is based. IIPs include seven entities: idiopathic pulmonary fibrosis, which is characterized by the morphologic pattern of usual interstitial pneumonia (UIP); nonspecific interstitial pneumonia (NSIP); cryptogenic organizing pneumonia (COP); respiratory bronchiolitis-associated interstitial lung disease (RB-ILD); desquamative interstitial pneumonia (DIP); lymphoid interstitial pneumonia (LIP); and acute interstitial pneumonia (AIP). The characteristic computed tomographic findings in UIP are predominantly basal and peripheral reticular opacities with honeycombing and traction bronchiectasis. In NSIP, basal ground-glass opacities tend to predominate over reticular opacities, with traction bronchiectasis only in advanced disease. COP is characterized by patchy peripheral or peribronchovascular consolidation. RB-ILD and DIP are smoking-related diseases characterized by centrilobular nodules and ground-glass opacities. LIP is characterized by ground-glass opacities, often in combination with cystic lesions. AIP manifests as diffuse lung consolidation with ground-glass opacities, which usually progress to fibrosis in patients who survive the acute phase of the disease. Correct diagnosis of IIPs can be achieved only by means of interdisciplinary consensus and stringent correlation of clinical, imaging, and pathologic findings. (c) RSNA, 2007.
美国胸科学会和欧洲呼吸学会于2002年发布的特发性间质性肺炎（IIP）分类，定义了IIP临床-放射-病理诊断所依据的形态学模式。IIP包括七个类型：特发性肺纤维化，其特征为普通型间质性肺炎（UIP）的形态学模式；非特异性间质性肺炎（NSIP）；隐源性机化性肺炎（COP）；呼吸性细支气管炎相关间质性肺疾病（RB-ILD）；脱屑性间质性肺炎（DIP）；淋巴细胞间质性肺炎（LIP）；以及急性间质性肺炎（AIP）。UIP的特征性计算机断层扫描表现主要为基底和周边的网状阴影伴蜂窝状改变和牵拉性支气管扩张。在NSIP中，基底磨玻璃影往往比网状阴影更常见，仅在疾病晚期出现牵拉性支气管扩张。COP的特征为斑片状周边或支气管血管周围实变。RB-ILD和DIP是与吸烟相关的疾病，特征为小叶中心结节和磨玻璃影。LIP的特征为磨玻璃影，常伴有囊性病变。AIP表现为弥漫性肺实变伴磨玻璃影，在疾病急性期存活的患者中通常会进展为纤维化。只有通过多学科共识以及临床、影像学和病理结果的严格关联，才能正确诊断IIP。（c）RSNA，2007年。
