Lamarche Benoît, Paradis Marie-Eve
Institute on Nutraceuticals and Functional Foods, Laval University, Québec, Canada.
Curr Opin Lipidol. 2007 Jun;18(3):298-303. doi: 10.1097/MOL.0b013e328133857f.
Several in-vitro and in-vivo animal studies indicate that endothelial lipase plays a key role in the intravascular remodeling of lipoproteins, particularly HDL. This review integrates this body of knowledge with more recent data in humans linking endothelial lipase to HDL metabolism and other features of the metabolic syndrome.
Human studies generally support the involvement of endothelial lipase in modulating plasma HDL. The association between endothelial lipase and metabolism of apolipoprotein B-containing lipoproteins in humans, however, has not been entirely consistent with previous findings in vitro and in animals. Finally, elevated plasma endothelial lipase has been associated with abdominal obesity and hypertension, and there is now compelling evidence that inflammation and in-vivo regulation of endothelial lipase may be intrinsically related.
Accumulating evidence indicates that endothelial lipase plays a role in the etiology of the atherogenic plasma lipoprotein profile characteristic of the metabolic syndrome. Increased endothelial lipase activity is linked to the underlying proinflammatory state in this condition. Further studies are required, however, to define the extent to which endothelial lipase contributes to the dyslipidemia of the metabolic syndrome relative to other important regulating factors, such as lipoprotein lipase, hepatic lipase, and cholesterol ester transfer protein.
多项体外和体内动物研究表明，内皮脂肪酶在脂蛋白尤其是高密度脂蛋白（HDL）的血管内重塑过程中起关键作用。本综述将这一知识体系与近期有关人类内皮脂肪酶与HDL代谢及代谢综合征其他特征之间联系的数据相结合。
人体研究总体上支持内皮脂肪酶参与调节血浆HDL。然而，人类内皮脂肪酶与含载脂蛋白B的脂蛋白代谢之间的关联，与先前体外和动物研究的结果并不完全一致。最后，血浆内皮脂肪酶升高与腹型肥胖和高血压相关，目前有确凿证据表明炎症与内皮脂肪酶的体内调节可能存在内在联系。
越来越多的证据表明，内皮脂肪酶在代谢综合征特征性致动脉粥样硬化血浆脂蛋白谱的病因中起作用。内皮脂肪酶活性增加与这种情况下潜在的促炎状态有关。然而，相对于其他重要调节因子，如脂蛋白脂肪酶、肝脂肪酶和胆固醇酯转运蛋白，仍需要进一步研究来确定内皮脂肪酶在代谢综合征血脂异常中所起作用的程度。
