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DNA damage check points prevent leukemic transformation in myelodysplastic syndrome.

作者信息

Horibe S, Takagi M, Unno J, Nagasawa M, Morio T, Arai A, Miura O, Ohta M, Kitagawa M, Mizutani S

出版信息

Leukemia. 2007 Oct;21(10):2195-8. doi: 10.1038/sj.leu.2404748. Epub 2007 May 10.

DOI:10.1038/sj.leu.2404748
PMID:17495965
Abstract
摘要

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1
DNA damage check points prevent leukemic transformation in myelodysplastic syndrome.DNA损伤检查点可预防骨髓增生异常综合征中的白血病转化。
Leukemia. 2007 Oct;21(10):2195-8. doi: 10.1038/sj.leu.2404748. Epub 2007 May 10.
2
Shwachman-Diamond syndrome: implications for understanding the molecular basis of leukaemia.施瓦赫曼-戴蒙德综合征：对理解白血病分子基础的启示
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Leukemic transformation in myelodysplastic syndrome: a review.骨髓增生异常综合征中的白血病转化：综述
Ann Clin Lab Sci. 1991 May-Jun;21(3):171-6.
4
[Study on the transformation from myelodysplastic syndromes into acute leukemias].[骨髓增生异常综合征向急性白血病转化的研究]
Zhonghua Xue Ye Xue Za Zhi. 2001 Jul;22(7):351-4.
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Expression of Toll-like receptor 9 in bone marrow cells of myelodysplastic syndromes is down-regulated during transformation to overt leukemia.Toll 样受体 9 在骨髓增生异常综合征向显性白血病转化过程中骨髓细胞的表达下调。
Exp Mol Pathol. 2010 Apr;88(2):293-8. doi: 10.1016/j.yexmp.2010.01.009. Epub 2010 Feb 2.
6
[Myelodysplastic syndromes: mechanisms of transformation and neoplastic progression and their clinical implications].
Haematologica. 1991 Jun;76 Suppl 3:75-84.
7
Leukemic transformation associated with massive hyperdiploidy in myelodysplastic syndrome (MDS) with der(1;7)(q10;p10): a novel case study.伴有der(1;7)(q10;p10)的骨髓增生异常综合征（MDS）中与大量超二倍体相关的白血病转化：一项新病例研究
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Mutation of p53 gene does not play a critical role in myelodysplastic syndrome and its transformation to acute leukaemia.p53基因的突变在骨髓增生异常综合征及其向急性白血病的转化过程中并不起关键作用。
Br J Haematol. 1992 Jul;81(3):456-7. doi: 10.1111/j.1365-2141.1992.tb08263.x.
9
N-ras mutation and karyotypic evolution are closely associated with leukemic transformation in myelodysplastic syndrome.N-ras 突变和核型演变与骨髓增生异常综合征的白血病转化密切相关。
Leukemia. 1994 Aug;8(8):1331-6.
10
Is inactivation of the p53 gene a common event in leukemias and myelodysplastic syndrome with monosomy 17p?
Leukemia. 1994 Jul;8(7):1247-8.

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Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia.基因和蛋白质分析显示，在细胞遗传学正常的急性髓系白血病和急性早幼粒细胞白血病中，p53通路在功能上失活。
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Innovative analyses support a role for DNA damage and an aberrant cell cycle in myelodysplastic syndrome pathogenesis.创新性分析支持DNA损伤和异常细胞周期在骨髓增生异常综合征发病机制中发挥作用。
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