Gao Feng, Zhang Chun-Ting
Department of Physics, Tianjin University, Tianjin 300072, China.
Bioinformatics. 2007 Jul 15;23(14):1866-7. doi: 10.1093/bioinformatics/btm255. Epub 2007 May 12.
Replication origins (oriCs) of bacterial genomes currently available in GenBank have been predicted by using a systematic method comprising the Z-curve analysis for nucleotide distribution asymmetry, DnaA box distribution, genes adjacent to candidate oriCs and phylogenetic relationships. These oriCs are organized into a MySQL database, DoriC, which provides extensive information and graphical views of the oriC regions. In addition, users can Blast a query sequence or even a whole genome against DoriC to find a homologous one. DoriC will be updated timely and the latest version is DoriC 1.8, in which oriCs of 425 genomes (468 chromosomes) are identified.
DoriC can be accessed from http://tubic.tju.edu.cn/doric/.
Supplementary data are available at http://tubic.tju.edu.cn/doric/supplementary.htm.
目前GenBank中可用的细菌基因组复制起点（oriC）已通过一种系统方法预测得出，该方法包括对核苷酸分布不对称性的Z曲线分析、DnaA框分布、候选oriC附近的基因以及系统发育关系。这些oriC被组织到一个MySQL数据库DoriC中，该数据库提供了oriC区域的广泛信息和图形视图。此外，用户可以针对DoriC对查询序列甚至整个基因组进行Blast以找到同源序列。DoriC将及时更新，最新版本是DoriC 1.8，其中识别出了425个基因组（468条染色体）的oriC。
可从http://tubic.tju.edu.cn/doric/访问DoriC。
