DEG：一个必需基因数据库。
DEG: a database of essential genes.
作者信息
Zhang Ren, Ou Hong-Yu, Zhang Chun-Ting
机构信息
Department of Epidemiology and Biostatistics, Tianjin Cancer Institute and Hospital, Tianjin 300060, China.
出版信息
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D271-2. doi: 10.1093/nar/gkh024.
Essential genes are genes that are indispensable to support cellular life. These genes constitute a minimal gene set required for a living cell. We have constructed a Database of Essential Genes (DEG), which contains all the essential genes that are currently available. The functions encoded by essential genes are considered a foundation of life and therefore are likely to be common to all cells. Users can BLAST the query sequences against DEG. If homologous genes are found, it is possible that the queried genes are also essential. Users can search for essential genes by their function or name. Users can also browse and extract all the records in DEG. Essential gene products comprise excellent targets for antibacterial drugs. Analysis of essential genes could help to answer the question of what are the basic functions necessary to support cellular life. DEG is freely accessible from the website http://tubic.tju.edu.cn/deg/.
必需基因是维持细胞生命不可或缺的基因。这些基因构成了活细胞所需的最小基因集。我们构建了一个必需基因数据库（DEG），其中包含了目前所有已知的必需基因。必需基因所编码的功能被视为生命的基础，因此可能为所有细胞所共有。用户可以将查询序列与DEG进行比对。如果找到同源基因，那么被查询的基因也有可能是必需基因。用户可以根据功能或名称搜索必需基因。用户还可以浏览和提取DEG中的所有记录。必需基因产物是抗菌药物的理想靶点。对必需基因的分析有助于回答维持细胞生命所需的基本功能是什么这一问题。可通过网站http://tubic.tju.edu.cn/deg/免费访问DEG。
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