带状疱疹后神经痛的预后。

The prognosis with postherpetic neuralgia.

作者信息

Watson Peter N C, Watt Verna R, Chipman Mary, Birkett Nicholas, Evans Ramon J

机构信息

Irene Eleanor Smythe Pain Clinic, Department of Anaesthesia, University of Toronto, Toronto, Ont.Canada, Clinical Research Support Group, Department of Epidemiology and Biostatistics, University of Toronto, Toronto, Ont.Canada Department of Epidemiology and Biostatistics, University of Ottawa, Ottawa, Ont.Canada.

出版信息

Pain. 1991 Aug;46(2):195-199. doi: 10.1016/0304-3959(91)90076-A.

DOI:10.1016/0304-3959(91)90076-A

PMID:1749643

Abstract

One hundred and fifty-six patients with moderate to severe postherpetic neuralgia (PHN) were followed for up to 11 years. Nearly half of all patients were doing well at the final assessment (median 2 years) and more than half of these were on no therapy at this time. The most commonly used agents associated with a good outcome were antidepressants, topical capsaicin and analgesics of various kinds. Longer duration PHN appeared to have a worse prognosis. More of these patients were noted to be using some form of treatment at follow up. A group of patients seemed to follow a progressive course and were refractory to all treatments used in this study.

摘要

156例中重度带状疱疹后神经痛（PHN）患者接受了长达11年的随访。在最终评估（中位时间为2年）时，近一半的患者情况良好，其中一半以上此时未接受任何治疗。与良好预后相关的最常用药物是抗抑郁药、外用辣椒素和各类镇痛药。病程较长的PHN预后似乎更差。在随访中，更多这类患者被发现正在使用某种形式的治疗。有一组患者似乎呈进行性病程，对本研究中使用的所有治疗均无效。