van der Velde Nathalie, van den Meiracker Anton H, Stricker Bruno H Ch, van der Cammen Tischa J M
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Blood Press Monit. 2007 Jun;12(3):167-71. doi: 10.1097/MBP.0b013e3280b083bd.
The role of orthostatic hypotension in falls in older people is generally accepted. Because of the high degree of intra- and interobserver variability in conventional measurements of orthostatic hypotension, application of continuous measurement systems has been proposed. The clinical relevance of a blood pressure drop lasting one heartbeat, however, is unknown. We therefore investigated which time average of continuous-finger-blood-pressure measurement (Finometer) showed the best association between orthostatic hypotension and falls. This was also compared with conventional sphygmomanometer measurements.
In 217 geriatric outpatients supine and standing (finger) blood pressure to diagnose orthostatic hypotension was monitored with Finometry (beat-to-beat and 1, 5, 10, 15, 20 and 30 s averages) and sphygmomanometry. History of fall incidents (previous year) was registered.
The best association (C=0.22, P=0.003) with falls history was found for the 5-s average of Finometry, whereas falls and orthostatic hypotension assessed by sphygmomanometry did not correlate. The odds ratio of a fall according to orthostatic hypotension using the 5-s average was 2.54 (95% CI: 1.37 to 4.71).
Orthostatic hypotension and falls are correlated when using Finometry, with the best association found when using 5-s averages. As the etiology of falls is often multifactorial, orthostatic hypotension and falls are poorly correlated, irrespective of the method or time average that is applied.
体位性低血压在老年人跌倒中所起的作用已得到普遍认可。由于体位性低血压传统测量方法在观察者内和观察者间的变异性很大,因此有人提出应用连续测量系统。然而,持续一个心跳的血压下降的临床相关性尚不清楚。因此,我们研究了连续手指血压测量(Finometer)的哪个时间平均值显示体位性低血压与跌倒之间的最佳关联。并将其与传统血压计测量结果进行比较。
对217名老年门诊患者采用Finometry(逐搏以及1、5、10、15、20和30秒平均值)和血压计监测仰卧位和站立位(手指)血压以诊断体位性低血压。记录跌倒事件史(前一年)。
Finometry的5秒平均值与跌倒史的关联最佳(C = 0.22,P = 0.003),而通过血压计评估的跌倒与体位性低血压不相关。使用5秒平均值时,根据体位性低血压发生跌倒的优势比为2.54(95%可信区间:1.37至4.71)。
使用Finometry时,体位性低血压与跌倒相关,使用5秒平均值时关联最佳。由于跌倒的病因通常是多因素的,无论采用何种方法或时间平均值,体位性低血压与跌倒的相关性都很差。