Baumann Oliver, Frank Gabriele, Rutschmann Roland M, Greenlee Mark W
Institute for Experimental Psychology, University of Regensburg, Regensburg, Germany.
Neuroreport. 2007 Mar 26;18(5):451-5. doi: 10.1097/WNR.0b013e32805868ba.
Blood oxygenation-level dependent changes in the cerebral cortex were measured using event-related functional magnetic resonance imaging in participants while they performed triple-step memory-guided saccades. To explore the role of dorsolateral prefrontal cortex in the manipulation of the contents of working memory, the sequence of saccade targets in the memory-guided task was either constant or was manipulated using coloured cues. The dorsolateral prefrontal cortex was significantly activated only during the period when participants had to reorder the locations of the saccade targets and not during the maintenance of spatial locations. This finding suggests that dorsolateral prefrontal cortex is primarily involved in the manipulation, and to a lesser extent, in the maintenance of the contents of working memory.
在参与者进行三步记忆引导扫视时，使用事件相关功能磁共振成像测量大脑皮层中血氧水平依赖的变化。为了探究背外侧前额叶皮层在工作记忆内容操作中的作用，记忆引导任务中扫视目标的顺序要么是固定的，要么使用颜色线索进行操纵。仅在参与者必须重新排列扫视目标位置的期间，背外侧前额叶皮层才会被显著激活，而在空间位置维持期间则不会。这一发现表明，背外侧前额叶皮层主要参与工作记忆内容的操作，在较小程度上也参与其维持。
