利用白细胞介素-12、白细胞介素-15和白细胞介素-7作为黏膜疫苗佐剂。
Utilizing IL-12, IL-15 and IL-7 as Mucosal Vaccine Adjuvants.
作者信息
Stevceva Liljana, Moniuszko Marcin, Ferrari Maria Grazia
机构信息
Partners AIDS Research Center, MGH, Harvard Medical School, CNY Build. 149, Room 5234e, Charlestown, MA 02129, USA.
出版信息
Lett Drug Des Discov. 2006;3(8):586-592. doi: 10.2174/157018006778194655.
Abstract
In this paper we review and discuss three of the most exciting and promising cytokines for therapeutic intervention and immunomodulation of immune responses including those on mucosal surfaces. The main properties of IL-12, IL-15 and IL-7 are described and the studies utilizing these cytokines as immunomodulators and vaccine adjuvants discussed.
摘要
在本文中，我们回顾并讨论了三种最令人兴奋且最具前景的细胞因子，它们可用于对免疫反应（包括黏膜表面的免疫反应）进行治疗干预和免疫调节。文中描述了白细胞介素-12（IL-12）、白细胞介素-15（IL-15）和白细胞介素-7（IL-7）的主要特性，并讨论了将这些细胞因子用作免疫调节剂和疫苗佐剂的研究。
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