Prso Ivana Brekalo, Kocjan Willy, Simić Hrvoje, Brumini Gordana, Pezelj-Ribarić Sonja, Borcić Josipa, Ferreri Silvio, Karlović Ivana Miletić
Department of Dentistry, Medical Faculty, University of Rijeka, HR 51000 Rijeka, Croatia.
Mediators Inflamm. 2007;2007:38210. doi: 10.1155/2007/38210. Epub 2006 Dec 27.
The aim of this study was to evaluate the presence of the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in human periapical lesions.
Samples were obtained from three groups of teeth: symptomatic teeth, asymptomatic lesions, and uninflamed periradicular tissues as a control.
TNF-alpha levels were significantly increased in symptomatic lesions compared to control. Group with asymptomatic lesions had significantly higher concentrations compared to control. There were no significant differences in TNF-alpha levels between symptomatic and asymptomatic lesions. In group with symptomatic lesions, IL-6 levels were significantly higher than in group with asymptomatic lesions. The IL-6 levels in symptomatic group also showed significantly higher concentration in comparison with control group. In asymptomatic group, the IL-6 level had significantly higher concentrations compared to control.
These results indicate that symptomatic lesions represent an immunologically active stage of disease, and asymptomatic lesions are the point from which the process advances toward healing.
本研究旨在评估细胞因子肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）在人类根尖周病变中的存在情况。
样本取自三组牙齿：有症状的牙齿、无症状病变以及作为对照的未发炎根尖周组织。
与对照组相比，有症状病变中TNF-α水平显著升高。无症状病变组的浓度显著高于对照组。有症状和无症状病变之间的TNF-α水平无显著差异。在有症状病变组中，IL-6水平显著高于无症状病变组。有症状组中的IL-6水平与对照组相比也显示出显著更高的浓度。在无症状组中，IL-6水平与对照组相比有显著更高的浓度。
这些结果表明，有症状病变代表疾病的免疫活跃阶段，而无症状病变是疾病进程朝着愈合发展的起点。
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