Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém-Pará, Brazil.
Department of Preventive and Social Dentistry, Faculty of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
Front Immunol. 2024 May 22;15:1366954. doi: 10.3389/fimmu.2024.1366954. eCollection 2024.
This systematic review aimed to verify whether there is evidence of an association between apical periodontitis and the presence of systemic biomarkers. This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses - PRISMA. For this, the acronym PECO was used; population (P) of adult humans exposed (E) to the presence of apical periodontitis, compared (C) to adult humans without apical periodontitis, and the outcome (O) of the presence of biomarkers was observed. The articles were searched in PubMed, Scopus, Web of Science, LILACS, Cochrane Library, OpenGray, and Google Scholar grey databases. Subsequently, studies were excluded based on title, abstract, and full article reading, following the eligibility criteria. The methodological quality of the selected studies was evaluated using the Newcastle-Ottawa qualifier. After exclusion, 656 studies were identified, resulting in 17 final articles that were divided into case-control, cross-sectional, and cohort studies. Eight studies were considered to have a low risk of bias, one had a medium risk of bias, and eight had a high risk of bias. In addition, 12 articles evaluated biomarkers in blood plasma, four evaluated them in saliva, and only one evaluated them in gingival crevicular fluid. The results of these studies indicated an association between apical periodontitis and the systemic presence of biomarkers. These markers are mainly related to inflammation, such as interleukins IL-1, IL-2, and IL-6, oxidative markers, such as nitric oxide and superoxide anions, and immunoglobulins IgG and IgM.
https://www.crd.york.ac.uk/prospero/, identifier (CRD42023493959).
本系统评价旨在验证根尖周炎与全身生物标志物之间是否存在关联。本研究遵循系统评价和荟萃分析的首选报告项目-PRISMA。为此，使用了首字母缩略词 PECO；（P）暴露于根尖周炎的成年人人群，（E）与无根尖周炎的成年人进行比较，（C）观察生物标志物的存在作为结局（O）。在 PubMed、Scopus、Web of Science、LILACS、Cochrane Library、OpenGray 和 Google Scholar 灰色数据库中搜索文章。随后，根据标题、摘要和全文阅读排除不符合纳入标准的研究。使用纽卡斯尔-渥太华量表评价选定研究的方法学质量。排除后，共确定 656 项研究，最终有 17 项符合条件的文章入选，分为病例对照、横断面和队列研究。8 项研究被认为具有低偏倚风险，1 项具有中偏倚风险，8 项具有高偏倚风险。此外，有 12 项研究评估了血浆中的生物标志物，4 项研究评估了唾液中的生物标志物，仅有 1 项研究评估了龈沟液中的生物标志物。这些研究的结果表明根尖周炎与全身生物标志物的存在存在关联。这些标志物主要与炎症有关，如白细胞介素 IL-1、IL-2 和 IL-6，氧化标志物，如一氧化氮和超氧阴离子，以及免疫球蛋白 IgG 和 IgM。
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