Boyle P A, Wilson R S, Buchman A S, Aggarwal N T, Tang Y, Arvanitakis Z, Kelly J, Bennett D A
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA.
Exp Aging Res. 2007 Jul-Sep;33(3):355-71. doi: 10.1080/03610730701319210.
Recent findings suggest that lower extremity motor dysfunction may be a feature of mild cognitive impairment (MCI), but little is known about the nature and significance of lower extremity motor dysfunction in MCI. The aim of this study was to examine the extent to which MCI is associated with impaired gait, balance, and strength and to examine the relation of lower extremity function to disability among persons with MCI in the Rush Memory and Aging Project, a clinical-pathologic study of common chronic conditions of old age. In a series of analyses adjusted for age, sex, and education, individuals with MCI exhibited more impaired gait and balance than individuals without cognitive impairment. Because vascular factors can contribute to lower extremity motor dysfunction, the authors repeated the initial analyses including terms for vascular risk factors and vascular disease, and the associations between MCI and lower extremity motor dysfunction persisted. Moreover, among those with MCI, impairments in gait and balance were associated with an increased likelihood of disability. These findings suggest that lower extremity motor dysfunction is common and contributes to disability in MCI, but lower extremity motor dysfunction in MCI does not appear to be explained by the vascular factors examined in this study.
最近的研究结果表明，下肢运动功能障碍可能是轻度认知障碍（MCI）的一个特征，但对于MCI中下肢运动功能障碍的性质和意义知之甚少。本研究的目的是在拉什记忆与衰老项目（一项关于老年人常见慢性病的临床病理研究）中，探讨MCI与步态、平衡和力量受损的关联程度，并研究MCI患者下肢功能与残疾之间的关系。在一系列针对年龄、性别和教育程度进行调整的分析中，与无认知障碍的个体相比，MCI个体表现出更严重的步态和平衡受损。由于血管因素可导致下肢运动功能障碍，作者重复了最初的分析，纳入了血管危险因素和血管疾病相关的变量，MCI与下肢运动功能障碍之间的关联依然存在。此外，在MCI患者中，步态和平衡受损与残疾可能性增加有关。这些发现表明，下肢运动功能障碍在MCI中很常见且会导致残疾，但本研究中所检测的血管因素似乎无法解释MCI中的下肢运动功能障碍。
