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自动筛查与手工筛查:在一项时间研究中对ThinPrep成像系统和手工筛查的比较。

Automated screening versus manual screening: a comparison of the ThinPrep imaging system and manual screening in a time study.

作者信息

Schledermann Doris, Hyldebrandt Tina, Ejersbo Dorthe, Hoelund Berit

机构信息

Department of Pathology, Odense University Hospital, Denmark.

出版信息

Diagn Cytopathol. 2007 Jun;35(6):348-52. doi: 10.1002/dc.20640.

Abstract

The ThinPrep Imaging System (TIS) is an automated system that assists cytotechnologists in the primary screening of ThinPrep liquid based cervical samples. Between June 1, 2004, and April 1, 2005, four experienced cytotechnologists participated in the study in which the duration of the screening procedure was timed for each of the 11,354 slides included. In every slide 22 fields of view were reviewed, and the samples that contained potentially abnormal cells were fully screened. The screening time was reduced by 42% (mean) (p < 0.001). By manual rescreening of the negative TIS samples, abnormal cells were found in 10 samples (false negative rate 0.14%). In every case the abnormal cells had been identified by the scanner, but misinterpreted by the cytotechnologist. These findings stressed the importance of carefulness in the interpretation of the marked fields and beyond that helped the cytotechnologists and pathologists to have more confidence in the automated system.

摘要

ThinPrep成像系统(TIS)是一种自动化系统,可协助细胞技术人员对ThinPrep液基宫颈样本进行初步筛查。在2004年6月1日至2005年4月1日期间,四名经验丰富的细胞技术人员参与了这项研究,对纳入的11354张玻片逐一记录筛查过程的持续时间。每张玻片检查22个视野,并对含有潜在异常细胞的样本进行全面筛查。筛查时间平均减少了42%(p<0.001)。通过对TIS阴性样本进行人工复查,在10个样本中发现了异常细胞(假阴性率为0.14%)。在每种情况下,异常细胞均已被扫描仪识别,但细胞技术人员解读错误。这些发现强调了在解读标记视野时要谨慎的重要性,此外,还帮助细胞技术人员和病理学家对自动化系统更有信心。

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