通过使用亚磺酰亚胺和前手性Weinreb酰胺烯醇盐对顺式-α-取代的β-氨基酮进行不对称合成。
Asymmetric synthesis of syn-alpha-substituted beta-amino ketones by using sulfinimines and prochiral Weinreb amide enolates.
作者信息
Davis Franklin A, Song Minsoo
机构信息
Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA.
出版信息
Org Lett. 2007 Jun 7;9(12):2413-6. doi: 10.1021/ol0708166. Epub 2007 May 11.
PMID:17497798
Abstract
Syn-alpha-substituted beta-amino Weinreb amides are new chiral building blocks for asymmetric synthesis of syn-alpha-substituted beta-amino acids, aldehydes, and ketones and are prepared by addition of prochiral lithium enolates of Weinreb amides to sulfinimines (N-sulfinyl imines).
摘要
顺式-α-取代的β-氨基Weinreb酰胺是用于不对称合成顺式-α-取代的β-氨基酸、醛和酮的新型手性砌块，可通过将Weinreb酰胺的前手性烯醇锂加成到亚磺酰亚胺（N-亚磺酰基亚胺）中来制备。
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