Li Zi-Bo, Liu Tian-Dong, Pu Lin
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904-4319, USA.
J Org Chem. 2007 Jun 8;72(12):4340-3. doi: 10.1021/jo070091j. Epub 2007 May 11.
The 1,1'-binaphthyl macrocycle (S)-2 is found to be an excellent catalyst for the alkyne addition to aldehydes. In the presence of (S)-2 (20 mol %) and Me2Zn (2 equiv) in THF at room temperature, the addition of phenylacetylene to linear or branched aliphatic aldehydes and vinyl aldehydes gave various propargylic alcohols with 89-96% ee.
发现1,1'-联萘大环化合物(S)-2是炔烃加成到醛类反应的优良催化剂。在室温下于四氢呋喃中，在(S)-2（20摩尔%）和二甲基锌（2当量）存在的情况下，苯乙炔加成到直链或支链脂肪醛以及乙烯基醛上，得到了对映体过量值为89 - 96%的各种炔丙醇。
