Abramson Jakub, Pecht Israel
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
Immunol Rev. 2007 Jun;217:231-54. doi: 10.1111/j.1600-065X.2007.00518.x.
The type I Fc epsilon receptor (Fc epsilon RI) is one of the better understood members of its class and is central to the immunological activation of mast cells and basophils, the key players in immunoglobulin E (IgE)-dependent immediate hypersensitivity. This review provides background information on several distinct regulatory mechanisms controlling this receptor's stimulus-response coupling network. First, we review the current understanding of this network's operation, and then we focus on the inhibitory regulatory mechanisms. In particular, we discuss the different known cytosolic molecules (e.g. kinases, phosphatases, and adapters) as well as cell membrane proteins involved in negatively regulating the Fc epsilon RI-induced secretory responses. Knowledge of this field is developing at a fast rate, as new proteins endowed with regulatory functions are still being discovered. Our understanding of the complex networks by which these proteins exert regulation is limited. Although the scope of this review does not include addressing several important biochemical and biophysical aspects of the regulatory mechanisms, it does provide general insights into a central field in immunology.
I型Fcε受体（FcεRI）是该类受体中了解较为深入的成员之一，对于肥大细胞和嗜碱性粒细胞的免疫激活至关重要，而肥大细胞和嗜碱性粒细胞是免疫球蛋白E（IgE）依赖性速发型超敏反应中的关键参与者。本综述提供了关于控制该受体刺激-反应偶联网络的几种不同调节机制的背景信息。首先，我们回顾一下目前对该网络运作的理解，然后重点关注抑制性调节机制。特别是，我们讨论了不同的已知胞质分子（如激酶、磷酸酶和衔接蛋白）以及参与负向调节FcεRI诱导的分泌反应的细胞膜蛋白。随着仍在发现具有调节功能的新蛋白质，该领域的知识正在迅速发展。我们对这些蛋白质发挥调节作用的复杂网络的理解是有限的。虽然本综述的范围不包括探讨调节机制的几个重要生化和生物物理方面，但它确实提供了对免疫学一个核心领域的总体见解。
