O'Sullivan Martin J, Morrow Monica
Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111-2497, USA.
Surg Clin North Am. 2007 Apr;87(2):333-51, viii. doi: 10.1016/j.suc.2007.01.006.
This article summarizes the modern evidence-based management of ductal carcinoma in situ. The data addressing the surgical issues, including indications for mastectomy and the use of sentinel node biopsy, are presented. The randomized trials examining the role of radiation therapy after breast-conserving surgery and the use of tamoxifen in ductal carcinoma in situ are discussed. Factors to consider in developing a management strategy for the individual patient are elucidated in the final section.
本文总结了导管原位癌的现代循证管理。文中呈现了涉及手术问题的数据，包括乳房切除术的适应证以及前哨淋巴结活检的应用。讨论了关于保乳手术后放疗作用以及他莫昔芬在导管原位癌中应用的随机试验。最后一部分阐明了为个体患者制定管理策略时需考虑的因素。
