Renoult Louis, Prévost Marie, Brodeur Mathieu, Lionnet Claire, Joober Ridha, Malla Ashok, Debruille J Bruno
Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada.
Schizophr Res. 2007 Jul;93(1-3):366-73. doi: 10.1016/j.schres.2007.03.024. Epub 2007 May 10.
The amplitude of the P300 event-related potential (ERP) has been reported to be reduced over left compared to right temporal sites in schizophrenia patients. This left temporal P300 reduction has been associated with positive symptom severity and gray matter reduction in the left superior temporal gyrus. We investigated a group of patients with a first episode of schizophrenia spectrum psychosis and a group of normal controls to verify if P300 amplitude asymmetry already exists around the time of presentation for treatment. Relative to normal control subjects, no P300 asymmetry was found in patients. Nevertheless, P300 asymmetry was correlated with the severity of positive symptoms and worse global functioning (GAF), a good predictor of poor outcome.
据报道，精神分裂症患者左侧颞叶部位的P300事件相关电位（ERP）波幅相较于右侧颞叶部位有所降低。左侧颞叶P300波幅降低与阳性症状严重程度以及左侧颞上回灰质减少有关。我们对一组首次发作的精神分裂症谱系精神病患者和一组正常对照者进行了研究，以验证在接受治疗时P300波幅不对称是否已经存在。与正常对照者相比，患者未发现P300不对称现象。然而，P300不对称与阳性症状严重程度以及较差的整体功能（GAF）相关，而GAF是预后不良的一个良好预测指标。
