Sweeney John A, Luna Beatriz, Keedy Sarah K, McDowell Jennifer E, Clementz Brett A
Center for Cognitive Medicine, University of Illinois at Chicago, 912 S. Wood Street (MC 913), Chicago, IL 60612-7327, USA.
Neuroimage. 2007;36 Suppl 2(Suppl 2):T54-60. doi: 10.1016/j.neuroimage.2007.03.018. Epub 2007 Mar 27.
Functional neuroimaging studies of eye movement control have been a useful approach for investigating the interaction of cognitive and sensorimotor brain systems. Building on unit recording studies of behaving nonhuman primates and clinical studies of patients with a focal brain lesion, functional neuroimaging studies have elucidated a pattern of hierarchical organization through which prefrontal and premotor systems interact with sensorimotor systems to support context-dependent adaptive behavior. Studies of antisaccades, memory-guided saccades, and predictive saccades have helped clarify how cognitive brain systems support contextually guided and internally generated action. The use of cognitive and sensorimotor eye movement paradigms is being used to develop a better understanding of life span changes in neurocognitive systems from childhood to late life, and about behavioral and systems-level brain abnormalities in neuropsychiatric disorders.
眼动控制的功能性神经影像学研究一直是探究认知与感觉运动脑系统相互作用的有效方法。基于对行为中的非人类灵长类动物的单位记录研究以及局灶性脑损伤患者的临床研究，功能性神经影像学研究阐明了一种层级组织模式，通过该模式前额叶和运动前系统与感觉运动系统相互作用，以支持依赖情境的适应性行为。对反扫视、记忆引导扫视和预测性扫视的研究有助于阐明认知脑系统如何支持情境引导和内在产生的行为。认知和感觉运动眼动范式的应用正有助于更好地理解从童年到老年神经认知系统的终生变化，以及神经精神疾病中的行为和系统层面的脑异常。
