Edry Efrat, Melamed Doron
Department of Immunology, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Clin Immunol. 2007 Jun;123(3):244-51. doi: 10.1016/j.clim.2007.02.008. Epub 2007 May 17.
The effector functions of the antibody are determined by the heavy chain constant region (CH). During CSR the primarily expressed mu constant region (Cmu) of the heavy chain is replaced with a downstream isotype Cgamma, Calpha or Cepsilon. The murine immunoglobulin heavy chain (IgH) locus contains eight different CH genes. Class switch recombination (CSR) involves a recombination between two different repetitive switch (S) region sequences, located upstream of each CH gene and the deletion of the intervening DNA. However, this protecting mechanism is also involved in aberrant chromosomal translocations and generation of B cell malignancies. It is also involved in susceptibility to autoimmunity. The current review focuses on the basic mechanism of CSR and the adverse outcomes that it may cause.
抗体的效应功能由重链恒定区（CH）决定。在类别转换重排（CSR）过程中，重链最初表达的μ恒定区（Cμ）被下游的同种型Cγ、Cα或Cε取代。小鼠免疫球蛋白重链（IgH）基因座包含八个不同的CH基因。类别转换重排（CSR）涉及位于每个CH基因上游的两个不同的重复开关（S）区域序列之间的重排以及中间DNA的缺失。然而，这种保护机制也与异常染色体易位和B细胞恶性肿瘤的发生有关。它还与自身免疫易感性有关。本综述重点关注CSR的基本机制及其可能导致的不良后果。
