Krishnaswamy K, Prasad C E, Murthy K J
Food and Drug Toxicology Research Centre, National Institute of Nutrition, Hyderabad, India.
Trop Geogr Med. 1991 Jan-Apr;43(1-2):156-60.
Adult undernourished tuberculous patients receiving isoniazid, rifampicin and ethambutol were evaluated clinically and biochemically for hepatic dysfunction. The nutritional status was assessed by body-mass index, serum albumin and haemoglobin. While only 11% of the patients developed jaundice, the majority of the patients had a significant elevation of the serum hepatic enzymes suggesting subclinical hepatotoxicity. A significant downward trend during the 3-6 months period was seen in patients with multiple estimations of SGOT and SGPT indicating a self-limiting toxic process. However, the continued elevation of GGT suggests enzyme induction by rifampicin. Undernutrition contributes to drug toxicity by various mechanisms. Therefore, it is important to evaluate the nutritional status of the tuberculous patients receiving drugs, which are potentially hepatotoxic.
对接受异烟肼、利福平及乙胺丁醇治疗的成年营养不良结核病患者进行了肝功能障碍的临床及生化评估。通过体重指数、血清白蛋白及血红蛋白评估营养状况。虽然仅有11%的患者出现黄疸，但大多数患者血清肝酶显著升高，提示存在亚临床肝毒性。多次测定谷草转氨酶（SGOT）和谷丙转氨酶（SGPT）的患者在3至6个月期间呈现出显著的下降趋势，表明这是一个自限性毒性过程。然而，γ-谷氨酰转移酶（GGT）持续升高提示利福平诱导酶的产生。营养不良通过多种机制导致药物毒性。因此，评估接受可能具有肝毒性药物治疗的结核病患者的营养状况非常重要。
