Sicotte Nancy L, Giesser Barbara S, Tandon Vinita, Klutch Ricki, Steiner Barbara, Drain Ann E, Shattuck David W, Hull Laura, Wang He-Jing, Elashoff Robert M, Swerdloff Ronald S, Voskuhl Rhonda R
Division of Brain Mapping, Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Arch Neurol. 2007 May;64(5):683-8. doi: 10.1001/archneur.64.5.683.
To study the effect of testosterone supplementation on men with multiple sclerosis (MS).
DESIGN, SETTING, AND PARTICIPANTS: Men are less susceptible to many autoimmune diseases, including MS. Possible causes for this include sex hormones and/or sex chromosome effects. Testosterone treatment ameliorates experimental allergic encephalomyelitis, an animal model of MS, but the effect of testosterone supplementation on men with MS is not known. Therefore, 10 men with relapsing-remitting MS were studied using a crossover design whereby each patient served as his own control. There was a 6-month pretreatment period followed by a 12-month period of daily treatment with 10 g of the gel containing 100 mg of testosterone.
Clinical measures of disability and cognition (the Multiple Sclerosis Functional Composite and the 7/24 Spatial Recall Test) and monthly magnetic resonance imaging measures of enhancing lesion activity and whole brain volumes.
One year of treatment with testosterone gel was associated with improvement in cognitive performance (P = .008) and a slowing of brain atrophy (P <.001). There was no significant effect of testosterone treatment on gadolinium-enhancing lesion numbers (P = .31) or volumes (P = .94). Lean body mass (muscle mass) was increased (P = .02).
These exploratory findings suggest that testosterone treatment is safe and well tolerated and has potential neuroprotective effects in men with relapsing-remitting MS.
研究补充睾酮对多发性硬化症（MS）男性患者的影响。
设计、地点和参与者：男性对包括MS在内的多种自身免疫性疾病的易感性较低。其可能原因包括性激素和/或性染色体的影响。睾酮治疗可改善MS动物模型实验性过敏性脑脊髓炎，但补充睾酮对MS男性患者的影响尚不清楚。因此，采用交叉设计对10例复发缓解型MS男性患者进行了研究，每位患者均作为自身对照。治疗前有6个月的准备期，随后是为期12个月的每日使用含100mg睾酮的凝胶10g进行治疗。
残疾和认知的临床指标（多发性硬化功能综合评分和7/24空间回忆测试）以及增强病灶活动和全脑体积的每月磁共振成像测量。
使用睾酮凝胶治疗一年与认知能力改善（P = 0.008）和脑萎缩减缓（P < 0.001）相关。睾酮治疗对钆增强病灶数量（P = .31）或体积（P = .94）无显著影响。瘦体重（肌肉量）增加（P = 0.02）。
这些探索性研究结果表明，睾酮治疗安全且耐受性良好，对复发缓解型MS男性患者具有潜在的神经保护作用。
Zotero 插件