Shahraki Zahra, Mohamadi Aida, Rastkar Mohsen, Ghajarzadeh Mahsa
Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran.
Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran.
J Family Reprod Health. 2023 Dec;17(4):194-198. doi: 10.18502/jfrh.v17i4.14590.
Multiple sclerosis is an autoimmune disease of central nervous system (CNS). There are a few articles studying the risk factors of developing MS in men. Male infertility can stem from a range of etiological factors such as genetics or environment. In the context of MS, research suggests a potential link, possibly due to shared immunological and inflammatory mechanisms. Therefore, we designed this study to evaluate the relationship between male infertility and MS development.
We systematically searched PubMed, Embase, Scopus, web of science, Google scholar and gray literature including references of the references as well as conference papers which were published up to June 2021. The search strategy in PubMed was ("Infertility, Male"[Mesh] OR [Male Infertility] OR [Sterility, Male] OR [Male Sterility] OR [Subfertility, Male] OR [Male Subfertility] OR [Sub-Fertility, Male] OR [Male Sub-Fertility] OR [Sub Fertility, Male]) AND ("Multiple Sclerosis"[Mesh] OR [Sclerosis, Multiple] OR [Sclerosis, disseminated] OR [Disseminated Sclerosis] OR [MS] OR [Multiple Sclerosis, Acute Fulminating]) AND ("Testicular Diseases"[Mesh] OR [Disease, Testicular] OR [Diseases, Testicular] OR [Testicular Disease]) AND ("Multiple Sclerosis"[Mesh] OR [Sclerosis, Multiple] OR [Sclerosis, disseminated] OR [Disseminated Sclerosis] OR [Multiple Sclerosis, Acute Fulminating] OR [MS]).
The literature search revealed 197 articles, after deleting duplicates 109 remained. For the meta-analysis, 3 studies were included. Totally, 2090 MS cases as well as 3895562 healthy subjects were enrolled. One hundred and fourteen infertile men were in MS group and 139716 infertile men were in controls. The pooled OR for male factor infertility and odds of developing MS was1.87 (95% CI: 0.89-3.94) (I=86.1%, P=0.001).
The results of this systematic review and meta-analysis show that there is no relationship between male factor infertility and risk of MS.
多发性硬化症是一种中枢神经系统（CNS）的自身免疫性疾病。目前研究男性患多发性硬化症风险因素的文章较少。男性不育可能源于一系列病因，如遗传或环境因素。在多发性硬化症的背景下，研究表明可能存在潜在联系，这可能是由于共同的免疫和炎症机制。因此，我们设计了本研究来评估男性不育与多发性硬化症发病之间的关系。
我们系统检索了截至2021年6月发表的PubMed、Embase、Scopus、科学网、谷歌学术以及灰色文献，包括参考文献的参考文献以及会议论文。PubMed的检索策略为（“男性不育症”[医学主题词]或[男性不育]或[男性不育症]或[男性不育]或[男性亚生育力]或[男性亚生育力]或[男性亚生育力]或[男性亚生育力]或[男性亚生育力]）与（“多发性硬化症”[医学主题词]或[多发性硬化症]或[播散性硬化症]或[播散性硬化症]或[MS]或[急性暴发性多发性硬化症]）与（“睾丸疾病”[医学主题词]或[睾丸疾病]或[睾丸疾病]或[睾丸疾病]）与（“多发性硬化症”[医学主题词]或[多发性硬化症]或[播散性硬化症]或[播散性硬化症]或[急性暴发性多发性硬化症]或[MS]）。
文献检索共得到197篇文章，剔除重复后剩余109篇。纳入荟萃分析的有3项研究。总共纳入了2090例多发性硬化症患者以及3895562名健康受试者。多发性硬化症组有114名不育男性，对照组有139716名不育男性。男性因素不育与患多发性硬化症几率的合并比值比为1.87（95%置信区间：0.89 - 3.94）（I² = 86.1%，P = 0.001）。
本系统评价和荟萃分析结果表明男性因素不育与多发性硬化症风险之间不存在关联。
