7至12岁儿童弱视治疗停止后视力改善的稳定性。
Stability of visual acuity improvement following discontinuation of amblyopia treatment in children aged 7 to 12 years.
作者信息
Hertle Richard W, Scheiman Mitchell M, Beck Roy W, Chandler Danielle L, Bacal Darron A, Birch Eileen, Chu Raymond H, Holmes Jonathan M, Klimek Deborah L, Lee Katherine A, Repka Michael X, Weakley David R
机构信息
Jaeb Center for Health Research, 15310 Amberly Drive, Tampa, FL 33647, USA.
出版信息
Arch Ophthalmol. 2007 May;125(5):655-9. doi: 10.1001/archopht.125.5.655.
OBJECTIVE
To assess the stability of visual acuity improvement during the first year after cessation of amblyopia treatment other than spectacle wear in children aged 7 to 12 years.
METHODS
At the completion of a multicenter randomized trial during which amblyopia treated with patching and atropine improved by at least 2 lines on the electronic Early Treatment of Diabetic Retinopathy Study testing protocol, 80 patients aged 7 to 12 years were followed up while not receiving treatment (other than spectacle wear) for 1 year.
MAIN OUTCOME MEASURE
Ten letters or more (> or =2 lines) worsening of visual acuity (measured using the electronic Early Treatment of Diabetic Retinopathy Study testing protocol) during the year following treatment discontinuation.
RESULTS
During the year following cessation of treatment, the cumulative probability of worsening visual acuity (> or =2 lines) was 7% (95% confidence interval, 3%-17%); 82% of patients maintained an increase in visual acuity of 10 letters or more compared with their visual acuity before starting treatment.
CONCLUSION
Visual acuity improvement occurring during amblyopia treatment is sustained in most children aged 7 to 12 years for at least 1 year after discontinuing treatment other than spectacle wear.
TRIAL REGISTRATION
ClinicalTrials.gov identifier: NCT00094692.
目的
评估7至12岁儿童停止除戴眼镜以外的弱视治疗后第一年视力改善情况的稳定性。
方法
在一项多中心随机试验结束时，对80例7至12岁的患者进行随访，这些患者在试验中接受遮盖和阿托品治疗的弱视在糖尿病视网膜病变早期治疗研究电子测试方案下视力至少提高了2行，随访期间不接受（除戴眼镜以外的）治疗，为期1年。
主要观察指标
治疗停止后1年内视力恶化10个字母或更多（≥2行，采用糖尿病视网膜病变早期治疗研究电子测试方案测量）。
结果
在停止治疗后的1年中，视力恶化（≥2行）的累积概率为7%（95%置信区间，3%-17%）；与开始治疗前的视力相比，82%的患者保持视力提高了10个字母或更多。
结论
7至12岁的大多数儿童在停止除戴眼镜以外的治疗后，弱视治疗期间出现的视力改善至少持续1年。
试验注册
ClinicalTrials.gov标识符：NCT00094692。
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