Repka Michael X, Cotter Susan A, Beck Roy W, Kraker Raymond T, Birch Eileen E, Everett Donald F, Hertle Richard W, Holmes Jonathan M, Quinn Graham E, Sala Nicholas A, Scheiman Mitchell M, Stager David R, Wallace David K
Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA.
Ophthalmology. 2004 Nov;111(11):2076-85. doi: 10.1016/j.ophtha.2004.04.032.
To compare daily atropine to weekend atropine as prescribed treatments for moderate amblyopia in children younger than 7 years.
Prospective, randomized multicenter clinical trial (30 sites).
One hundred sixty-eight children younger than 7 years with amblyopia in the range of 20/40 to 20/80 associated with strabismus, anisometropia, or both.
Randomization either to daily atropine or to weekend atropine for 4 months. Partial responders were continued on the randomized treatment until no further improvement was noted.
Visual acuity (VA) in the amblyopic eye after 4 months.
The improvement in VA of the amblyopic eye from baseline to 4 months averaged 2.3 lines in each group. The VA of the amblyopic eye at study completion was either (1) at least 20/25 or (2) better than or equal to that of the sound eye in 39 children (47%) in the daily group and 45 children (53%) in the weekend group. The VA of the sound eye at the end of follow-up was reduced by 2 lines in one patient in each group. Stereoacuity outcomes were similar in the 2 groups.
Weekend atropine provides an improvement in VA of a magnitude similar to that of the improvement provided by daily atropine in treating moderate amblyopia in children 3 to 7 years old. This article contains additional online-only material available at http://www.ophsource.com/periodicals/ophtha.
比较每日使用阿托品与周末使用阿托品作为7岁以下儿童中度弱视的规定治疗方法。
前瞻性、随机多中心临床试验（30个地点）。
168名7岁以下患有弱视的儿童，弱视程度在20/40至20/80之间，伴有斜视、屈光参差或两者皆有。
随机分为每日使用阿托品组或周末使用阿托品组，为期4个月。部分反应者继续接受随机治疗，直至未见进一步改善。
4个月后弱视眼的视力（VA）。
每组中弱视眼从基线到4个月的视力改善平均为2.3行。在每日用药组的39名儿童（47%）和周末用药组的45名儿童（53%）中，研究结束时弱视眼的视力要么（1）至少达到20/25，要么（2）优于或等于健眼。每组各有一名患者在随访结束时健眼视力下降了2行。两组的立体视锐度结果相似。
对于3至7岁儿童的中度弱视，周末使用阿托品使视力提高的幅度与每日使用阿托品相似。本文包含额外的在线独家材料，可在http://www.ophsource.com/periodicals/ophtha获取。
