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[子痫前期的心血管系统。需治疗的病理生理学及后遗症]

[The cardiovascular system in pre-eclampsia. Pathophysiology and sequelae to be treated].

作者信息

Schwarz R

机构信息

Universitäts-Frauenklinik, Rostock, Bundesrepublik Deutschland.

出版信息

Zentralbl Gynakol. 1991;113(18):971-80.

PMID:1750296
Abstract

Physiologic alterations of the cardiovascular system during normal pregnancy are the basis of all discussions about the problem of preeclampsia and treatment. The main point has to be the sufficient blood supply to the fetus. In this review cardiovascular alterations in high and low pressure system have been reported. High arterial blood pressure, elevated total peripheral resistance, reduced plasma volume, hemoconcentration, reduced suspension stability and hyperviscosity are symptoms which can be treated. Clinical experiences with a hemodynamic adjusted treatment, giving firstly infusionary therapy for correcting hypovolemia with the aim of an improvement within the low pressure system which cause an increase of cardiac output and then secondly the use of only such antihypertensive drugs having favourable effects on the uteroplacental blood flow are good and confirm theoretical considerations.

摘要

正常妊娠期间心血管系统的生理改变是所有关于子痫前期问题及治疗讨论的基础。关键在于为胎儿提供充足的血液供应。本综述报道了高低压系统中的心血管改变。动脉血压升高、总外周阻力增加、血浆容量减少、血液浓缩、悬浮稳定性降低和血液高黏滞度等症状是可以治疗的。血流动力学调整治疗的临床经验良好,首先进行输液治疗以纠正血容量不足,目的是改善低压系统,从而增加心输出量,其次仅使用对子宫胎盘血流有有利影响的降压药物,这证实了理论上的考虑。

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