黏附G蛋白偶联受体：一类独特的G蛋白偶联受体家族，在中枢和外周组织中均发挥重要作用。
The adhesion GPCRs: a unique family of G protein-coupled receptors with important roles in both central and peripheral tissues.
作者信息
Bjarnadóttir T K, Fredriksson R, Schiöth H B
机构信息
Department of Neuroscience, Uppsala University, BMC, Box 593, 751 24, Uppsala, Sweden.
出版信息
Cell Mol Life Sci. 2007 Aug;64(16):2104-19. doi: 10.1007/s00018-007-7067-1.
G protein-coupled receptors (GPCRs) are a diverse superfamily of membrane-bound receptors. The second largest subgroup of GPCRs, the Adhesion GPCRs, has 33 members in humans. Phylogenetic analysis of the entire repertoire of the seven transmembrane- domain (7TM) regions of GPCRs shows that the Adhesion GPCRs form a distinct family. Adhesion GPCRs are characterised by (1) long N termini with multiple functional domains often found in other proteins such as tyrosine kinases, integrins and cadherins, (2) highly complex genomic structure with multiple introns and splice variants and (3) a 7TM region that has no clear similarities with 7TM from other GPCRs. Several Adhesion GPCRs are known to have a role in the immune system but it is becoming more evident that many have important roles in the CNS. We speculate that the overall structural construction of the Adhesion GPCRs allows them to participate in different types of cell guidance.
G蛋白偶联受体（GPCRs）是一类多样的膜结合受体超家族。GPCRs的第二大亚组，即粘附GPCRs，在人类中有33个成员。对GPCRs的整个七跨膜结构域（7TM）区域库进行系统发育分析表明，粘附GPCRs形成了一个独特的家族。粘附GPCRs的特征在于：（1）长的N末端带有多个通常在其他蛋白质（如酪氨酸激酶、整合素和钙粘蛋白）中发现的功能域；（2）具有多个内含子和剪接变体的高度复杂基因组结构；（3）一个与其他GPCRs的7TM没有明显相似性的7TM区域。已知几种粘附GPCRs在免疫系统中发挥作用，但越来越明显的是，许多粘附GPCRs在中枢神经系统中具有重要作用。我们推测，粘附GPCRs的整体结构构造使其能够参与不同类型的细胞导向。
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