Stasević Zvonimir, Subarić-Gorgieva Gordana, Krcmarević Jelica, Stolić Radoica, Trajković Goran
Srp Arh Celok Lek. 2007 Jan-Feb;135(1-2):48-53. doi: 10.2298/sarh0702048s.
Hemodialysis efficacy that significantly influences morbidity and mortality of patients can be evaluated by different widely used indices of adequacy.
The aim of the study was to evaluate the adequacy of hemodialysis in the group of patients on maintenance hemodialysis and to examine the influence of different dialysis membranes on the indices of adequacy and frequency of symptoms and complications developing during dialysis treatment.
The study involved 14 patients dialyzed in three successive months with three different types of dialyzers: E3 (Hemomed)--cuprophane membrane, 1.3 m2, F6 (Hemomed)--polysulfone membrane, 1.3 m2, CM23 (Zdravlje)--cuprophane membrane, 1.25 m2. Each type of dialyzers was used during one month, meaning during 12 successive 4-hour hemodialyses.
Mean value of Kt/V index was 1.39 +/- 0.21 for E3 dialyzer, 1.18 +/- 0.24 for F6 dialyzer and 1.44 +/- 0.25 for CM23 dialyzer. The difference between the indices was statistically significant (p < 0.05). Mean protein catabolic rate (PCRn) ranged between 1.6 and 1.7 and no significant difference was found between the dialyzers used. The frequency of hypertension episodes was similar during the hemodialysis with different dialyzers, but the incidence of different symptoms and hypotension episodes was significantly lower during hemodialysis with polysulfone membrane.
Hemodialysis with three examined types of dialyzers enabled acceptable dialysis adequacy. Dialyzers with cuprophane membrane enabled significantly higher Kt/V index, but the incidence of symptoms and hypotension was significantly lower during hemodialysis with polysulfone membrane.
可通过不同广泛使用的充分性指标来评估对患者发病率和死亡率有显著影响的血液透析疗效。
本研究旨在评估维持性血液透析患者群体的血液透析充分性，并研究不同透析膜对充分性指标以及透析治疗期间症状和并发症发生频率的影响。
本研究纳入14例患者，连续三个月使用三种不同类型的透析器进行透析：E3（Hemomed）——铜仿膜，1.3平方米；F6（Hemomed）——聚砜膜，1.3平方米；CM23（Zdravlje）——铜仿膜，1.25平方米。每种类型的透析器使用一个月，即连续进行12次4小时的血液透析。
E3透析器的Kt/V指数平均值为1.39±0.21，F6透析器为1.18±0.24，CM23透析器为1.44±0.25。这些指数之间的差异具有统计学意义（p<0.05）。平均蛋白分解代谢率（PCRn）在1.6至1.7之间波动，所使用的透析器之间未发现显著差异。使用不同透析器进行血液透析期间高血压发作的频率相似，但使用聚砜膜进行血液透析期间不同症状和低血压发作的发生率显著较低。
使用三种检测类型的透析器进行血液透析可实现可接受的透析充分性。铜仿膜透析器可使Kt/V指数显著更高，但使用聚砜膜进行血液透析期间症状和低血压的发生率显著更低。
