Escobar C, Barrios V, Calderón A, Llisterri J L, García S, Rodríguez-Roca G C, Matalí A
Instituto de Enfermedades del Corazón, Hospital Ramón y Cajal, Carretera del Colmenar km. 9,100, 28034 Madrid, Spain.
Rev Clin Esp. 2007 May;207(5):221-7. doi: 10.1157/13102313.
The aim of this study was to determine the blood pressure and LDL-cholesterol (LDL-c) control rates of hypertensive patients with diabetes mellitus attended in primary care setting in Spain, and to compare the data with those of the hypertensive population without diabetes. For this purpose, we analyzed the subset of diabetic patients of those included in the PRESCOT study (a cross-sectional survey of hypertensive subjects > 18 years attended in primary care). 12,954 patients (49.9% females; 62.1 +/- 10.7 years) were included in the PRESCOT study. Good controls were considered blood pressure < 130/80 mmHg (according to European Society of Hypertension-European Society of Cardiology [ESH-ESC] guidelines) and LDL-c < 100 mg/dl (National Cholesterol Education Program-Adult Treatment Panel III [NCEP-ATP III]).
Overall, 3868 (29.9%) of PRESCOT patients were diabetics (mean age 64.2 +/- 9.8 years; 47.5% males). Almost all the diabetic patients (98.5%) were taking some drug besides the antidiabetic treatment and 84.9% were taking at least 2 drugs. Although diabetic patients were treated with more antihypertensive medication than those without diabetes (48.75% vs 40.85% were on > 2 drugs, p < 0.001), blood pressure control was much lower in diabetics (6.3% vs 32.7%, p < 0.0001). In the same way, LDL-c control was also lower in these patients (12.0% vs 31.9%, p < 0.0001). Only 1.0% of diabetic hypertensives were well controlled for both risk factors (vs 11.9% of non-diabetics, p < 0.0001). Predictors of bad blood pressure control were sedentarism and presence of associated clinical conditions, and for lipid control the younger age, female gender, overweight, alcoholism and non-use of lipid-lowering agents.
The presence of diabetes in hypertensive population attended in Spanish primary health care is frequent. One out of every three hypertensives who attend the outpatient clinic daily is diabetic. Even though more drugs are prescribed in these patients, blood pressure and LDL-c control rates are significantly lower than in patients without diabetes. In the daily practice of primary care setting, almost no diabetic hypertensive subject is well controlled for blood pressure and LDL-c.
本研究旨在确定西班牙基层医疗环境中糖尿病高血压患者的血压和低密度脂蛋白胆固醇(LDL-c)控制率,并将数据与无糖尿病的高血压人群进行比较。为此,我们分析了PRESCOT研究(一项针对基层医疗中年龄大于18岁的高血压患者的横断面调查)中糖尿病患者的子集。PRESCOT研究纳入了12,954例患者(女性占49.9%;年龄62.1±10.7岁)。良好控制定义为血压<130/80 mmHg(根据欧洲高血压学会 - 欧洲心脏病学会[ESH-ESC]指南)和LDL-c<100 mg/dl(美国国家胆固醇教育计划成人治疗小组第三次报告[NCEP-ATP III])。
总体而言,PRESCOT研究中有3868例(29.9%)患者患有糖尿病(平均年龄64.2±9.8岁;男性占47.5%)。几乎所有糖尿病患者(98.5%)除接受抗糖尿病治疗外还服用其他药物,84.9%的患者至少服用2种药物。尽管糖尿病患者服用的降压药物比无糖尿病患者多(服用超过2种药物的比例分别为48.75%和40.85%,p<0.001),但糖尿病患者的血压控制率低得多(分别为6.3%和32.7%,p<0.0001)。同样,这些患者的LDL-c控制率也较低(分别为12.0%和31.9%,p<0.0001)。只有1.0%的糖尿病高血压患者两个危险因素均得到良好控制(非糖尿病患者为11.9%,p<0.0001)。血压控制不佳的预测因素为久坐不动和存在相关临床疾病,而血脂控制不佳的预测因素为年龄较小、女性、超重、酗酒和未使用降脂药物。
在西班牙基层医疗中就诊的高血压人群中糖尿病很常见。每天到门诊就诊的高血压患者中每三人就有一人患有糖尿病。尽管这些患者服用的药物更多,但血压和LDL-c控制率显著低于无糖尿病患者。在基层医疗的日常实践中,几乎没有糖尿病高血压患者的血压和LDL-c得到良好控制。